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Clinical Chemistry 47: 2164-2165, 2001;
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(Clinical Chemistry. 2001;47:2164-2165.)
© 2001 American Association for Clinical Chemistry, Inc.

Articles

Cell-free Fetal DNA Is Increased in Plasma of Women with Hyperemesis Gravidarum

Akihiko Sekizawaa, Yumi Sugito, Mariko Iwasaki, Akira Watanabe, Masatoshi Jimbo, Shinichi Hoshi, Hiroshi Saito and Takashi Okai

Department of Obstetrics and Gynecology, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan

aauthor for correspondence: fax 81-33784-8355, e-mail sekizawa@d8.dion.ne.jp


   Introduction
 
Nausea and vomiting of moderate intensity are especially common complaints in early gestation. Hyperemesis gravidarum (HG), which is the most severe form of this disorder, occurs in 0.5–2% of pregnancies and is associated with weight loss, ketonemia, ketonuria, electrolyte imbalance, dehydration, and possible hepatic and renal damage.

Recently, the presence of cell-free fetal DNA in maternal plasma or serum has been demonstrated (1). It has been reported that the concentration of fetal DNA in maternal plasma is increased in pregnancies involving preterm delivery (2), preeclampsia (3)(4), and trisomy 21 (5)(6). In the present study, we evaluated the concentration of fetal DNA in maternal plasma in HG patients.

Pregnant women diagnosed with HG and admitted to Showa University Hospital were recruited. In this study, HG was defined according to the following criteria: (a) persistent nausea and vomiting; (b) weight loss (>2 kg); and (c) ketonuria (>2+, urine dipstick). Maternal blood samples were obtained at the time of admission from 35 patients with HG carrying a single fetus between 7 and 16 weeks of gestation. Sixteen of 35 blood samples collected . . . [Full Text of this Article]


   Acknowledgments
 

   References
 



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Cell-free fetal DNA in the maternal circulation does not stem from the transplacental passage of fetal erythroblasts
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