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Clinical Chemistry 47: 782-783, 2001;
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(Clinical Chemistry. 2001;47:782-783.)
© 2001 American Association for Clinical Chemistry, Inc.

Technical Briefs

Cardiac Troponin T Is Not Detected in Western Blots of Diseased Renal Tissue

Gershwin K. Davis1, Ralf Labugger2, Jennifer E. Van Eyk2 and Fred S. Apple1,a

1 Hennepin County Medical Center, Clinical Laboratories, Minneapolis MN 55415

2 Department of Physiology, Queens University, Kingston, Ontario, K7L 3N6 Canada
a author for correspondence: fax 612-904-4229; e-mail fred.apple@co.hennepin.mn.us

Recent publications of consensus documents for the redefinition of myocardial infarction are heavily predicated on the role of increases in cardiac troponin (I or T) in serum in the setting of ischemic symptoms (1)(2)(3)). Cardiac troponin T (cTnT) has also been reported to be a predictor of mortality in patients with end stage renal disease (4)(5). An unexplained increase in the frequency of increased serum cTnT compared with serum cardiac troponin I has been described in these patients (6)(7). Explanations advanced for this difference include the possibility of nonspecific reactions in the cTnT assay or de novo expression of cTnT in skeletal muscle of renal diseased patients that is subsequently released into the serum (8). However, recent studies on skeletal muscle from renal disease patients have shown that although the two antibodies used in the cTnT diagnostic assay (M7 and M11.7) individually bind to muscle proteins, this would not cause false-positive results in the current-generation cTnT assay marketed by Roche (8). On the other hand, cardiac troponin I is not expressed in fetal or in healthy or diseased adult human skeletal tissue (9). An additional possibility is that cTnT or other immunoreactive proteins are being expressed . . . [Full Text of this Article]


References




The following articles in journals at HighWire Press have cited this article:


Home page
 jvdiHome page
M. S. Willis, J. A. Snyder, R. H. Poppenga, and D. G. Grenache
Bovine cardiac troponin T is not accurately quantified with a common human clinical immunoassay
J Vet Diagn Invest, January 1, 2007; 19(1): 106 - 108.
[Abstract] [Full Text] [PDF]

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 CirculationHome page
N. A. Khan, B. R. Hemmelgarn, M. Tonelli, C. R. Thompson, and A. Levin
Prognostic Value of Troponin T and I Among Asymptomatic Patients With End-Stage Renal Disease: A Meta-Analysis
Circulation, November 15, 2005; 112(20): 3088 - 3096.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
D. Ritter, P. A. Lee, J. F. Taylor, L. Hsu, J. D. Cohen, H. D. Chung, and K. S. Virgo
Troponin I in Patients without Chest Pain
Clin. Chem., January 1, 2004; 50(1): 112 - 119.
[Abstract] [Full Text] [PDF]

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 J Am Coll CardiolHome page
B. J. Freda, W. H. W. Tang, F. Van Lente, W. F. Peacock, and G. S. Francis
Cardiac troponins in renal insufficiency: Review and clinical implications
J. Am. Coll. Cardiol., December 18, 2002; 40(12): 2065 - 2071.
[Abstract] [Full Text] [PDF]

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 J Am Coll CardiolHome page
A. S. Jaffe
Testing the wrong hypothesis: the failure to recognize the limitations of troponin assays
J. Am. Coll. Cardiol., October 1, 2001; 38(4): 999 - 1001.
[Full Text] [PDF]


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