Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 47: 1332-1333, 2001;
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (24)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Butler, S. A.
Right arrow Articles by Cole, L. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Butler, S. A.
Right arrow Articles by Cole, L. A.
Related Collections
Right arrow Endocrinology and Metabolism
(Clinical Chemistry. 2001;47:1332-1333.)
© 2001 American Association for Clinical Chemistry, Inc.

Letters

Use of Heterophilic Antibody Blocking Agent (HBT) in Reducing False-Positive hCG Results

Stephen A. Butler1a and Laurence A. Cole1

1 USA hCG Reference Service, Department of Obstetrics and Gynecology, University of New Mexico, 2211 Lomas Blvd., Albuquerque, NM 87131


aAuthor for correspondence. Fax 505-272-3576; e-mail Stephen@hcglab.com.


To the Editor:

The USA hCG Reference Service aids physicians in the interpretation of discordant or irregular human chorionic gonadotropin (hCG) results that do not concur with physical findings. The Service has now observed 24 cases of false-positive hCG results (14–571 IU/L). All have been cases erroneously diagnosed with choriocarcinoma or gestational trophoblast disease without demonstrable pregnancy or tumor (1)(2)(3)(4). Because of false-positive hCG results, patients have needlessly received chemotherapy, hysterectomy, and/or other surgery. The suspected cause for serum false-positive hCG is the presence of heterophilic antibodies that bind both capture and detection antibodies, effectively bridging them in the same way as the target antigen should in a standard ELISA format.

Until . . . [Full Text of this Article]


References




The following articles in journals at HighWire Press have cited this article:


Home page
 Annals of Clinical & Laboratory ScienceHome page
C. L Buckner, L. Wilson, and C. N. Papadea
An Unusual Cause of Elevated Serum Total {beta}hCG
Ann. Clin. Lab. Sci., January 1, 2007; 37(2): 186 - 191.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
C. M. Preissner, L. A. Dodge, D. J. O'Kane, R. J. Singh, and S. K.G. Grebe
Prevalence of Heterophilic Antibody Interference in Eight Automated Tumor Marker Immunoassays
Clin. Chem., January 1, 2005; 51(1): 208 - 210.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
P. von Lode, J. Rainaho, and K. Pettersson
Quantitative, Wide-Range, 5-Minute Point-of-Care Immunoassay for Total Human Chorionic Gonadotropin in Whole Blood
Clin. Chem., June 1, 2004; 50(6): 1026 - 1035.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. F. Emerson, G. Ngo, and S. S. Emerson
Screening for Interference in Immunoassays
Clin. Chem., July 1, 2003; 49(7): 1163 - 1169.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
N. Esfandiari and J. M. Goldberg
Heterophile Antibody Blocking Agent to Confirm False Positive Serum Human Chorionic Gonadotropin Assay
Obstet. Gynecol., May 1, 2003; 101(5): 1144 - 1146.
[Abstract] [Full Text] [PDF]

Home page
 Obstet GynecolHome page
S. A. Butler, L. A. Cole, T. G. Olsen, P. R. Hubert, L. R. Nycum, and C. B. Hammond
Falsely Elevated Human Chorionic Gonadotropin Leading to Unnecessary Therapy
Obstet. Gynecol., March 1, 2002; 99(3): 516 - 517.
[Full Text] [PDF]

Home page
 Clin. Chem.Home page
R. Sapin and C. Simon
False Hyperprolactinemia Corrected by the Use of Heterophilic Antibody-blocking Agent
Clin. Chem., December 1, 2001; 47(12): 2184 - 2185.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American Association for Clinical Chemistry.