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Serum C-Reactive Protein in Canadian Inuit and Its Association with Genetic Variation on Chromosome 1q21

¹ John P. Robarts Research Institute, London, Ontario, N6A 5K8 Canada

² Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, R3E 0W3 Canada

^aaddress correspondence to this author at: Blackburn Cardiovascular Genetics Laboratory, John P. Robarts Research Institute, 406-100 Perth Dr., London, Ontario, N6A 5K8 Canada; fax 519-663-3789, e-mail robert.hegele@rri.on.ca

Mortality from cardiovascular disease among Inuit living in the far north of Canada is 40% lower than in the rest of the country (1). This might be attributable to the protection resulting from environmental factors such as dietary -3 fatty acids in Arctic fish (1). Genetic factors may also be important. For example, the thermolabile variant of methylenetetrahydrofolate reductase is much less prevalent among Inuit than among subjects of European origin (2). However, there are also paradoxical genetic findings in these people. For example, some common genetic variants associated with a higher risk of cardiovascular disease, such as the APOE E4 and AGT T235 alleles, are more prevalent among Inuit than among subjects of European origin (3). These apparent inconsistencies may be related to the fact that there are numerous determinants of susceptibility to cardiovascular disease and that these determinants may differ among ethnic groups (4). As newer determinants of cardiovascular disease risk are identified, these can be evaluated in the Inuit.

C-Reactive protein (CRP), an acute-phase reactant originally detected through its interaction with pneumococcal C polysaccharide (5), has been proposed to be a risk factor for cardiovascular disease (6). When detected with a high-sensitivity assay (6), increased serum CRP could be related to increased vascular disease risk either directly through its association with inflammation (7) or indirectly through its association with obesity and insulin resistance (8). The serum CRP concentration in the Inuit . . . [Full Text of this Article]

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References

The following articles in journals at HighWire Press have cited this article:

				F. G. Hage and A. J. Szalai C-Reactive Protein Gene Polymorphisms, C-Reactive Protein Blood Levels, and Cardiovascular Disease Risk J. Am. Coll. Cardiol., September 18, 2007; 50(12): 1115 - 1122. [Abstract] [Full Text] [PDF]