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Clinical Chemistry 48: 183-185, 2002;
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(Clinical Chemistry. 2002;48:183-185.)
© 2002 American Association for Clinical Chemistry, Inc.

Technical Briefs

Plasma Homocysteine Concentrations in Patients with Liver Cirrhosis

Natàlia Ferré1, Frederic Gómez, Jordi Camps1a, Josep M. Simó1, Michelle M. Murphy2, Joan Fernández-Ballart2 and Jorge Joven1

1 Centre de Recerca Biomèdica and
2 Unitat de Medicina Preventiva, Facultat de Medicina i Ciències de la Salut, Institut de Recerca en Ciències de la Salut, Hospital Universitari de Sant Joan, C/. Sant Joan s/n, 43201-Reus, Catalunya, Spain;

aauthor for correspondence: fax 34-977-312569, e-mail jcamps@grupsgs.com

Plasma homocysteine (tHcy) is a marker of folate or cobalamin deficiency states (1) and a risk factor for cardiovascular diseases (2), and is altered by renal insufficiency (3). Increased tHcy in liver diseases may also play a role in hepatic disorders (4)(5). Chronic treatment of experimental animals with ethanol or CCl4 is associated with hyperhomocysteinemia, and the hepatoprotective effect of S-adenosylmethionine on experimental cirrhosis is accompanied by a normalization of methionine metabolism and a decrease in tHcy concentration (4)(5). Studies in cultured hepatocytes suggest a role of the liver in metabolism of Hcy (6). However, the presence and degree of hyperhomocysteinemia in patients with liver disease and its modulation by chronic alcohol intake are, as yet, not well defined.

We studied 76 patients with liver cirrhosis (55 men and 21 women; age range, 57 ± 11 years) who were being treated in the outpatient clinic of Hospital Universitari de Sant Joan. The diagnosis of cirrhosis was based on liver biopsy or on clinical evidence, including echography to evaluate splenomegaly and portal vein dilation and fiber-optic gastroscopy to detect the presence of gastroesophageal varices. The etiology of cirrhosis was alcoholic in 48 patients (63%) and . . . [Full Text of this Article]


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Elevated Homocysteine Concentrations in Liver Cirrhosis - A Result of Renal Impairment ?
Rainer P Woitas, et al.
Clinical Chemistry Online, 16 Jan 2002 [Full text]

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