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1 Department of Pathology, and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon
aAddress correspondence to this author at: Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, PO 11-0236, Beirut, Lebanon. Fax 961-1-370845; e-mail rd02@aub.edu.lb.
To the Editor:
Clinical toxicology in emergency situations necessitates the availability of rapid analytical tests for different substances in a variety of settings. The primary question asked by clinicians is what compounds may have been ingested. In cases of suspected drug abuse or overdose, rapid screening by immunoassays has made this possible. However, many limitations are inherent in these methods, which necessitate confirmation by an alternative method such as gas chromatography-mass spectrometry (1). Here we present a case of drug interference with certain screening methods for opiates in urine.
A 7-year-old male (Table 1
, patient 1) presented to the emergency unit at the American University of Beirut Medical Center with a progressive decrease in his level of consciousness over the previous 3 weeks. He was transferred from another hospital because of a suspicion of tuberculous meningitis. As part of the workup for this case,
Acknowledgments
References
The following articles in journals at HighWire Press have cited this article:
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M. G. Fitzsimons, K. H. Baker, E. Lowenstein, and W. M. Zapol Random Drug Testing to Reduce the Incidence of Addiction in Anesthesia Residents: Preliminary Results from One Program Anesth. Analg., August 1, 2008; 107(2): 630 - 635. [Abstract] [Full Text] [PDF] |
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G. M. Reisfield, E. Salazar, and R. L. Bertholf Rational Use and Interpretation of Urine Drug Testing in Chronic Opioid Therapy Ann. Clin. Lab. Sci., January 1, 2007; 37(4): 301 - 314. [Abstract] [Full Text] [PDF] |
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J. L Zacher and D. M Givone False-Positive Urine Opiate Screening Associated with Fluoroquinolone Use Ann. Pharmacother., September 1, 2004; 38(9): 1525 - 1528. [Abstract] [Full Text] [PDF] |
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