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Clinical Chemistry 48: 204-205, 2002;
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(Clinical Chemistry. 2002;48:204-205.)
© 2002 American Association for Clinical Chemistry, Inc.

Letters

Effect of Piperacillin-Tazobactam on Clinical Capillary Zone Electrophoresis of Serum Proteins

Xavier Bossuyt1a and Willy E. Peetermans2

1 Laboratory Medicine, Immunology and
2 Internal Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Herestraat 49, B-3000 Leuven, Belgium

aAuthor for correspondence. E-mail xavier.bossuyt@uz.kuleuven.ac.be.


To the Editor:

Over the last 5 years, capillary zone electrophoresis (CZE) has emerged as an automated technique for the separation of serum proteins in clinical laboratories (1)(2)(3)(4)(5). In conventional methods, quantification of the protein fractions is based on dye binding, whereas CZE uses ultraviolet detection at 214 nm for direct protein quantification via the peptide bonds. Any substance or drug that is present in serum and that absorbs at 214 nm potentially can interfere with CZE analysis. It has been reported that radio-contrast media, which absorb at 214 nm, interfere with CZE and can simulate a monoclonal component (. . . [Full Text of this Article]


References




The following articles in journals at HighWire Press have cited this article:


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S. Neale, A. Brown, J. Jeffery, and R. M Ayling
Drug Monitoring and Toxicology (DMT)
Clin. Chem., January 1, 2008; 54(1): 218 - 220.
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X. Bossuyt, J. Verhaegen, G. Marien, and N. Blanckaert
Effect of Sulfamethoxazole on Clinical Capillary Zone Electrophoresis of Serum Proteins
Clin. Chem., February 1, 2003; 49(2): 340 - 341.
[Full Text] [PDF]


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