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Clinical Chemistry 48: 207-208, 2002;
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Right arrow Endocrinology and Metabolism
(Clinical Chemistry. 2002;48:207-208.)
© 2002 American Association for Clinical Chemistry, Inc.

Letters

Comparison of Two Methods for Measuring Salivary Cortisol

Hershel Raff1,2a, Peter J. Homar1 and Edith A. Burns2,3

1 Endocrine Research Laboratory, St. Luke’s Medical Center, Milwaukee, WI 53215

2 Department of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226

3 Clement J. Zablocki, VA Medical Center, Milwaukee, WI 53295

aAddress correspondence to this author at: Endocrinology and Diabetes, St. Luke’s Physician’s Office Building, 2801 W KK River Pkwy., Suite 245, Milwaukee, WI 53215. Fax 414-649-5747; e-mail hraff@mcw.edu.


To the Editor:

The concentration of cortisol in the saliva reflects the activity of the hypothalamic-pituitary-adrenal axis (1), and an increased late-night salivary cortisol has >95% sensitivity and specificity for Cushing syndrome (1)(2).

We compared a commonly used modification of a RIA for serum cortisol with a new enzyme immunoassay (EIA) specifically designed to measure salivary cortisol in 352 saliva samples. The first samples (n = 195) were sent to our laboratory to screen for Cushing syndrome; all were collected at 2300 from 90 patients (age range, 17–77 years; 74 women and 16 men). The second set of samples (n = 104) was obtained at 2300 and 0700 from healthy, elderly patients (n = 52; age range, 67–82 years; 21 women and 31 men) who were part of a large, longitudinal study (3). The third set of samples (n = 53) was obtained at 2300 and 0700 from a group of apparently healthy individuals (n . . . [Full Text of this Article]


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The following articles in journals at HighWire Press have cited this article:


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D. A. Papanicolaou, N. Mullen, I. Kyrou, and L. K. Nieman
Nighttime Salivary Cortisol: A Useful Test for the Diagnosis of Cushing's Syndrome
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