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Clinical Chemistry 48: 2082-2083, 2002;
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(Clinical Chemistry. 2002;48:2082-2083.)
© 2002 American Association for Clinical Chemistry, Inc.

Letters

Serologic Testing for Celiac Disease

Daniela Basso1, Graziella Guariso2 and Mario Plebani1a

Departments of
1 Laboratory Medicine, and
2 Pediatrics, University-Hospital of Padova, 35128 Padova, Italy

aAuthor for correspondence. E-mail mario.plebani@sanito.padova.it.

The first 20% of the full text of this article appears below.


To the Editor:

We read with interest the report by Martini et al. (1). The authors compared the accuracy of five commercially available IgA anti-tissue transglutaminase (anti-tTG) ELISAs with data from anti-endomysial antibodies (EmAs) in the diagnosis and follow-up of adult patients with celiac disease (CD) and supported the superiority of the EmA test over ELISAs. They reported high sensitivities and specificities for some ELISAs that overlapped those of the EmA test.

We studied 285 children (107 males, 178 females; mean age, 8 years; range, 2–18 years), of whom 134 had CD and had been on a gluten-free diet for 3 (n = 17), 6 (n = 9), 12 (n = 16), 24 (n = 19), or >24 (n = 73) months. Histology in 108 children after 1 year on the diet showed a consistent improvement or complete recovery in all cases. One hundred fifty-one of the patients were . . . [Full Text of this Article]




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