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Clinical Chemistry 48: 391-a, 2002;
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(Clinical Chemistry. 2002;48:391.)
© 2002 American Association for Clinical Chemistry, Inc.

Letters

Screening for Hemoglobin Variants with Abnormal Oxygen Affinity

Robert W. Burnett1a

1 Department of Pathology and Laboratory Medicine, Hartford Hospital, Hartford, CT 06102

aE-mail rburnet@harthosp.org


To the Editor:

Rai et al. (1) recently described an elegant method for detecting hemoglobin (Hb) variants that cause erythrocytosis, using electrospray mass spectrometry. Many of these variants are not detectable with conventional electrophoretic techniques. The authors also stated that "functional studies of oxygen saturation curves would be the ideal method to screen . . . [Full Text of this Article]


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