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Clinical Chemistry 48: 677-679, 2002;
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(Clinical Chemistry. 2002;48:677-679.)
© 2002 American Association for Clinical Chemistry, Inc.

Letters

False-Positive Troponin I Attributed to a Macrocomplex

Mario Plebani1a, Monica Mion1, Sara Altinier1, Maria Antonia Girotto2, Goretta Baldo3 and Martina Zaninotto1

1 Department of Laboratory Medicine, Azienda Ospedaliera, 35128 Padova, Italy

2 Department of Laboratory Medicine, Hospital of Rovigo, 45100 Rovigo, Italy

3 Department of Medical, and Surgical Sciences, University of Padova, 35128 Padova, Italy

aAuthor for correspondence. Fax 39-049-663-240; e-mail pad08821@pd.nettuno.it.


To the Editor:

Cardiac troponins (I and T) represent a major improvement in the biochemical approach to the detection and evaluation of myocardial damage (1)(2). Here, we describe a case in which the measurement of cardiac troponin I (cTnI) gave erroneous clinical information because of interference caused by the presence of a macrocomplex.

The patient, a 78-year-old Caucasian woman with a pacemaker, had a long-standing history of cardiac disease, including a myocardial infarction 1 year before (July 1999), transient ischemic episodes with chest pain, and mitral valve failure. On July 22, 2000, the patient was admitted to the cardiac intensive care unit for an episode of chest pain and dyspnea. On admission, no significant electrocardiographic alterations were found. Biochemical markers were measured on several occasions (e.g., Table 1 ). Reference values were according to the manufacturers and confirmed in our population. At admission, cTnI and myoglobin (RxL Dimension; Dade-Behring) were increased (1.0 and 96 µg/L, respectively; reference values <0.05 and <70 µg/L), but creatine kinase MB (CK-MB) was not (2 . . . [Full Text of this Article]


References




The following articles in journals at HighWire Press have cited this article:


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Serum Troponins as Biomarkers of Drug-Induced Cardiac Toxicity
Toxicol Pathol, January 1, 2004; 32(1): 106 - 121.
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Coronary Artery Disease and the Acute Coronary Syndrome
Ann Intern Med, December 2, 2003; 139(11): W-82 - W-82.
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S. Eriksson, M. Junikka, P. Laitinen, K. Majamaa-Voltti, H. Alfthan, and K. Pettersson
Negative Interference in Cardiac Troponin I Immunoassays from a Frequently Occurring Serum and Plasma Component
Clin. Chem., July 1, 2003; 49(7): 1095 - 1104.
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