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The Serum S100B Concentration Is Age Dependent

¹ Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, RS, 90035-003 Brazil

² Laboratório Municipal de Novo Hamburgo, RS, 93310-003 Brazil

³ Departamento de Psiquiatria do Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, 90035-003 Brazil

⁴ Centro de Cirurgia de Epilepsia, CIREP, Hospital de Clínicas, FMRP-USP, Campus Universitário, Ribeirão Preto, SP, 14048-900 Brazil

⁵ Laboratório de Patologia Clínica, HSL-PUCRS, Porto Alegre, RS, 91530-001 Brazil

⁶ Serviço de Hemoterapia, Hemosul, Cachoeira do Sul, RS, 96508-970 Brazil

^aaddress correspondence to this author at: Departamento de Bioquímica, ICBS, UFRGS, Rua Ramiro Barcelos 2600-Anexo, Porto Alegre, RS, 90035-003 Brazil; e-mail diogo@ufrgs.br

S100B is a 21-kDa calcium-binding protein produced and released primarily by astrocytes in the central nervous system (CNS), where it exerts neurotropic and gliotropic actions (1). Several studies have investigated the potential role of S100B as a peripheral biochemical marker of neural injury, including reactive gliosis, astrocytic death, and/or blood-brain barrier dysfunction (2). Increased cerebrospinal fluid (CSF) and/or serum S100B has been reported in several acute and chronic injuries, including traumatic brain injury (3), stroke (4), Alzheimer disease (5), schizophrenia (6), HTLV-I-associated myelopathy (7), and systemic lupus erythematosus (8).

Previous neurodevelopmental studies have demonstrated age-related changes in S100B tissue expression and distribution in the CNS in mammals, which may be related to the different roles of this protein in distinct brain regions during the fetal period, adulthood, and aging (1)(9). Furthermore, S100B concentrations in CSF have been noted to increase with age in healthy individuals (10). Because these increases are more evident in men than women (11), S100B concentrations in CSF may be sex and age dependent, suggesting that age- and sex-matched controls may be necessary for studies of S100B in CSF. To determine the usual concentrations for plasma S100B in adults, Wiesmann et al. (12) measured the protein in healthy blood donors and found no differences with sex and age in individuals 18–65 years of age, in agreement with our findings in previous studies in adults (6)(7)(8).

To our knowledge, however, S100B concentrations in blood in childhood and adolescence were not established until recently. The present study was performed to verify S100B serum concentrations in healthy individuals of different ages, ranging from neonates to adults.

We collected . . . [Full Text of this Article]

Acknowledgments

References

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