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Clinical Chemistry 48: 1210-1211, 2002;
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(Clinical Chemistry. 2002;48:1210-1211.)
© 2002 American Association for Clinical Chemistry, Inc.

Editorial

Progress in the Knowledge of Circulating Nucleic Acids: Plasma RNA Is Particle-Associated. Can It Become a General Detection Marker for a Cancer Blood Test?

Philippe Ankera1 and Maurice Stroun1

1 Extracellular Biology Research Laboratory, 7 Route de Drize Carouge, 1227 Geneva, Switzerland

aAuthor for correspondence. E-mail Panker@worldcom.ch.

The first 20% of the full text of this article appears below.

A simple blood test for cancer detection has been the quest of many researchers. Thus, the finding that cell-free circulating DNA in the plasma of cancer patients has characteristics of tumor DNA has produced much interest. In fact, in the last few years, more than 200 publications on this topic have appeared in the literature.

In the 1970s, early studies showed that increased quantities of DNA could be found in the plasma of patients suffering from different malignancies (1). Later it was reported that this circulating extracellular DNA exhibits tumor-related alterations, such as decreased strand stability (2), Ras or p53 mutations, microsatellite alterations, aberrant promoter hypermethylation of tumor suppressor genes, rearranged immunoglobulin heavy-chain DNA, mitochondrial DNA mutations, and tumor-related viral DNA (3).

The success of viral DNA as a tumor marker in plasma/serum has been rapid because of the development by the group headed by Dennis Lo in Hong Kong of a method of accurately quantifying viral DNA in the circulation (4). This very active group has been able, . . . [Full Text of this Article]




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