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Clinical Chemistry 49: 2102-2103, 2003; 10.1373/clinchem.2003.024232
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(Clinical Chemistry. 2003;49:2102-2103.)
© 2003 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Detection of Hereditary Persistence of {alpha}-Fetoprotein by Conformation-sensitive Gel Electrophoresis Analysis

José R. Blesa1, José Vidal2, Remedios Giner-Durán2, María L. Lacalle1, Ignacio Catalán2 and José Hernández-Yago1,a

1 Fundación Valenciana, de Investigaciones Biomédicas, Instituto de Investigaciones Citológicas, Amadeo de Saboya, 4, 46010 Valencia, Spain
2 Hospital "Arnau de Vilanova", San Clemente 12, 46015 Valencia, Spain

aAddress correspondence to this author at: Fundación Valenciana de Investigaciones Biomédicas, Laboratory of Cell Organization, Amadeo de Saboya, 4, 46010 Valencia, Spain. Fax 34-963601453; e-mail hernan@ochoa.fib.es.

The first 20% of the full text of this article appears below.


To the Editor:

The concentration of human {alpha}-fetoprotein (AFP; MIM 104150) is used as a marker for several diseases in both adults and children, and it is also systematically measured in pregnant women as a marker of defects in the fetus.

In 1983, a case was discovered of a woman with high AFP expression that was shown to be attributable to a benign autosomal dominant genetic trait, hereditary persistence of AFP (HPAFP) (1). This syndrome shows high expression of AFP, but there is no association with any pathology. Failure to recognize HPAFP can lead to unsuitable treatments. For example, a 20-month-old child with HPAFP underwent surgery for a testicular germ cell tumor (2. . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
Y. Alj, E. Milgrom, and A. Guiochon-Mantel
Rapid Determination of {alpha}-Fetoprotein Gene Promoter Mutations in Hereditary Persistence of {alpha}-Fetoprotein
Clin. Chem., September 1, 2004; 50(9): 1706 - 1707.
[Full Text] [PDF]


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