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Clinical Chemistry 49: 2108-2109, 2003; 10.1373/clinchem.2003.025437
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(Clinical Chemistry. 2003;49:2108-2109.)
© 2003 American Association for Clinical Chemistry, Inc.


Letters to the Editor

Detection of SARS Coronavirus RNA in the Cerebrospinal Fluid of a Patient with Severe Acute Respiratory Syndrome

Emily C.W. Hung1, Stephen S.C. Chim2, Paul K.S. Chan3, Yu K. Tong2, Enders K.O. Ng2, Rossa W.K. Chiu2, Chi-Bon Leung4, Joseph J.Y. Sung4, John S. Tam3 and Y.M. Dennis Lo2,a

Departments of1 Paediatrics,2 Chemical Pathology,3 Microbiology, and4 Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region

aAuthor for correspondence. Fax 852-2194-6171; e-mail loym@cuhk.edu.hk.

The first 20% of the full text of this article appears below.


To the Editor:

Severe acute respiratory syndrome (SARS) is a recently emerged disease caused by a novel coronavirus, the SARS coronavirus (SARS-CoV) (1)(2). Although the respiratory manifestations of SARS are well recognized, the neurologic manifestations have been much less studied (1). Here we report a SARS patient with clinical and laboratory evidence of neurologic involvement.

A 59-year-old woman with IgA nephropathy was admitted to the Prince of Wales Hospital in Hong Kong in early May 2003 because of swinging fever, chills, productive cough, and diarrhea. She was previously admitted in April with fungal peritonitis related to her peritoneal dialysis. Despite antifungal and antibiotic therapy, her respiratory function deteriorated. She became increasingly dyspneic and required supplemental oxygen. High-resolution computer . . . [Full Text of this Article]




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Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R373 - R381.
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K.W. Tsang, G.C. Ooi, and P.L. Ho
Diagnosis and pharmacotherapy of severe acute respiratory syndrome: what have we learnt?
Eur. Respir. J., December 1, 2004; 24(6): 1025 - 1032.
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W. G. Glass, K. Subbarao, B. Murphy, and P. M. Murphy
Mechanisms of Host Defense following Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) Pulmonary Infection of Mice
J. Immunol., September 15, 2004; 173(6): 4030 - 4039.
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