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Clinical Chemistry 49: 813-815, 2003; 10.1373/49.5.813
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(Clinical Chemistry. 2003;49:813-815.)
© 2003 American Association for Clinical Chemistry, Inc.

Technical Briefs

Influence of Sampling-Time Error on Cyclosporine Measurements Nominally at 2 Hours after Administration

Frank Saint-Marcoux1, Annick Rousseau1,2, Yann Le Meur3, Marc Estenne4, Christiane Knoop4, Jean Debord1 and Pierre Marquet1,a

Departments of
1 Pharmacology and Toxicology and
3 Nephrology, University Hospital, 87042 Limoges cedex, France
2 Laboratory of Biophysics, Faculty of Pharmacy, 87025 Limoges cedex, France

4 Departments of Chest Medicine and Clinical Chemistry, Erasme University Hospital, 1070 Brussels, Belgium

aaddress correspondence to this author at: Service de Pharmacologie et Toxicologie, CHU Dupuytren, 87042 Limoges cedex, France; fax 33-555-05-61-62, e-mail marquet@unilim.fr

The first 300 words of the full text of this article appear below.

Cyclosporine (CsA) blood concentrations measured 2 h after Neoral® administration (c2) are a sensitive predictor of clinical outcome in organ transplantation, as suggested by a recent prospective clinical trial in liver transplant patients (1). c2 is now recommended as the target exposure index for the therapeutic drug monitoring (TDM) of CsA (2)(3)(4)(5)(6)(7)(8). The aim of this study was to investigate, for different types of grafts, the concentration–time relationships around c2 to evaluate the concentration error as a function of the sampling-time error and to identify the sampling-time range compatible with acceptable performance of this c2 TDM strategy.

Data obtained from three different clinical trials were studied retrospectively. Each patient gave written informed consent, and each trial was approved by a local ethics committee (9)(10)(11). The three populations were as follows:






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