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Clinical Chemistry 49: 835, 2003; 10.1373/49.5.835
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(Clinical Chemistry. 2003;49:835.)
© 2003 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Addition of 3-Deazaadenosine to Vacutainer Tubes Stabilizes Whole-Blood Homocysteine for At Least 6 Hours at Ambient Temperature

Ann Bowrona and David Stansbie

Department of Clinical Biochemistry, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom

aAuthor for correspondence. Fax 44-0117-928-3107; e-mail ann.bowron@ubht.swest.nhs.uk.

The first 20% of the full text of this article appears below.


To the Editor:

Increased plasma homocysteine is now well established as a risk factor for cardiac, cerebral, and peripheral vascular disease (1). Despite this, the test is not widely available. This is partly because of practical difficulties in sample collection. The homocysteine concentration increases in whole blood by up to 10% per hour unless samples are kept on ice and separated within 60 min.

The introduction of containers with 3-deazaadenosine (3-dad; DS30 Homocysteine Blood Collection Tubes; Drew Scientific Ltd.), described in a recent report (2) in the Journal, may solve the problem, but they are . . . [Full Text of this Article]






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