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Clinical Chemistry 49: 836-837, 2003; 10.1373/49.5.836
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(Clinical Chemistry. 2003;49:836-837.)
© 2003 American Association for Clinical Chemistry, Inc.

Letters

Reference Values for Serum S-100B Protein Depend on the Race of Individuals

Ouardia Ben Abdesselam1, Josette Vally1, Camilo Adem2, Marie-José Foglietti1 and Jean-Louis Beaudeux1,a

1 Service de Biochimie C and

2 Service d’Anatomie et Cytologie Pathologiques (Pr F. Capron) Groupe Hospitalier Pitié-Salpêtrière 47-83 bd de l’hôpital 75651 Paris Cedex 13, France

aAuthor for correspondence. Fax 33-1-4217-7616; e-mail jean-louis.beaudeux@psl.ap-hop-paris.fr.

The first 20% of the full text of this article appears below.


To the Editor:

S-100B is expressed by cells of neuroectodermal origin, particularly cerebral glial cells (astrocytes), and in several tumor processes, including malignant melanocytic lesions (1). Although S-100B is localized primarily in the intracellular compartment, it is physiologically detectable in biological fluids (cerebrospinal fluid, serum, and urine). Measurement of S-100B has been proposed as a biological marker of brain damage, e.g., head injury, cerebral hypoxia, and stroke (2), and of malignant melanoma(3). Serum S-100B values in healthy individuals range from 0.02 to 0.15 µg/L, as determined by immunoluminometric analytical methods. Although studies are controversial, S-100B concentrations in biological fluids appear to be age- and sex-dependent (4)(5)(6)(7). No information is available regarding potential differences according to the race or ethnicity of . . . [Full Text of this Article]






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