HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Submit an electronic Letter to the Editor about this paper Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (10) Citing Articles via Google Scholar Google Scholar Articles by Arndt, T. Search for Related Content PubMed PubMed Citation Articles by Arndt, T. Related Collections Drug Monitoring and Toxicology Endocrinology and Metabolism

Asialotransferrin—An Alternative to Carbohydrate-deficient Transferrin?

Bioscientia GmbH, Konrad-Adenauer-Strasse 17, D-55218 Ingelheim, Germany, Fax 49-6132-781-428, E-mail arndt@bioscientia.de

The first 20% of the full text of this article appears below.

To the Editor:

Asialotransferrin, monosialotransferrin, and disialotransferrin are collectively referred to as carbohydrate-deficient transferrin (CDT) (1)(2). Over the last several years, the definition of CDT has become increasingly vague (which transferrin isoforms are CDT isoforms and which are not). Thus, different transferrin isoforms are analyzed with various recoveries as CDT (2). The lack of standardization of CDT analysis complicates the preanalysis, analysis, and interpretation of CDT. To overcome this problem, consistent use of the CDT definition introduced by Stibler (1), a redefinition of CDT, or replacement by a clearly defined analyte is needed (2).

In our laboratory, using isoelectric focusing for transferrin isoform analysis (3)(4)(5), we observed a high prevalence of bands for asialotransferrin and monosialotransferrin, plus an increased fraction of disialotransferrin, in serum samples with increased CDT. In contrast, samples from healthy persons (with typical alcohol intake and CDT values within the reference interval) usually did not show asialo- and monosialotransferrin bands. Similar observations have been reported by others (1)(2). This prompted the suggestion to replace the analyte group CDT by asialotransferrin as a clearly defined analyte (6). However, there has not been a sufficiently sensitive and quantitative analytical method available to investigate the value of asialotransferrin as a marker of . . . [Full Text of this Article]

The following articles in journals at HighWire Press have cited this article:

				J.-B. Daeppen, F. Anex, B. Favrat, A. Bissery, J. Leutwyler, R. Gammeter, P. Mangin, and M. Augsburger Carbohydrate-Deficient Transferrin Measured by Capillary Zone Electrophoresis and by Turbidimetric Immunoassay for Identification of Young Heavy Drinkers Clin. Chem., June 1, 2005; 51(6): 1046 - 1048. [Full Text] [PDF]

				R. Schwan, L. Malet, M.N. Loiseaux, and P.M. Llorca Which Types of Alcohol-Use Disorder Will Asialotransferrin Detect? Clin. Chem., April 1, 2004; 50(4): 782 - 782. [Full Text] [PDF]

				A. Helander, A. Husa, and J.-O. Jeppsson Improved HPLC Method for Carbohydrate-deficient Transferrin in Serum Clin. Chem., November 1, 2003; 49(11): 1881 - 1890. [Abstract] [Full Text] [PDF]