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Clinical Chemistry 49: 1025-1026, 2003; 10.1373/49.6.1025
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(Clinical Chemistry. 2003;49:1025-1026.)
© 2003 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Increased Carbohydrate-deficient Transferrin of Unknown Etiology in a 15-Year-Old Male Patient with Autoimmune Hepatitis Type 1

Torsten Arndt1,a, Dorothee Kuhn1, Hermann Herbst2, Markus Linnemann3 and Nikolaos Nikolaidis4

1 Bioscientia GmbH, Konrad Adenauer Strasse 17, D-55218 Ingelheim, Germany

2 Gerhard-Domagk-Institut für Pathologie, Universität Münster
Domagkstrasse 17 D-48149 Münster, Germany

3 Laborarztpraxis Dr. Linnemann, Grabbeallee 34, 13156 Berlin, Germany

4 Abteilung für Innere Medizin, St. Elisabeth Hospital, Elisabethstrasse 10, D-59269 Beckum, Germany

aAuthor for correspondence. Fax 49-6132-781-428, e-mail arndt@bioscientia.de.

The first 20% of the full text of this article appears below.


To the Editor:

Carbohydrate-deficient transferrin (CDT) is currently the most specific laboratory marker of chronic alcohol abuse (1). We report a 15-year-old boy with autoimmune hepatitis type 1, increased serum CDT, and no history of alcohol abuse. The case is particularly important because patients in the early phase of autoimmune hepatitis may be asymptomatic. The diagnostic criteria for autoimmune hepatitis (2), which were used for our patient, are summarized together with the patient’s data in the Data Supplement that accompanies the online version of this letter at http://www.clinchem.org/content/vol49/issue6/.

The patient was admitted for evaluation of icterus ~1 week in duration, decreased performance, and fatigue for ~6 months. He had mild splenomegaly, and biopsy revealed developing micronodular cirrhosis. The patient’s denial of alcohol intake was confirmed by his mother and by AUDIT (3) and MALT-F scores (4). One week before admission, the patient had herpes zoster treated successfully with . . . [Full Text of this Article]






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