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Effect of Anti-Carbonic Anhydrase Antibodies on Carbonic Anhydrases I and II

¹ Controllo e Gestione delle Merci e del oro Impatto sull’Ambiente Department and
² Department of Pharmacology and General Physiology, "La Sapienza" University of Rome, 00161 Rome, Italy

³ Institute of Internal Medicine, Department of Medicine, Surgery and Dentistry, University of Milan, 20142 Milan, Italy

^aaddress correspondence to this author at: CGMIA Department, University of Rome "La Sapienza", Via del Castro Laurenziano 9, 00161 Rome, Italy; fax 39-06-23310228, e-mail botre@uniroma1.it

The first 300 words of the full text of this article appear below.

Carbonic anhydrase (CA; EC 4.2.1.1) is a zinc enzyme that is widely distributed in the living world and is involved in many biochemical processes that depend on the hydration/dehydration of carbon dioxide/bicarbonate [reviewed in Refs. (1)(2)(3)(4)(5)(6)].

Anti-CA antibodies have been identified, isolated, and purified from patients with a wide range of diseases, for some of which their presence can be a reliable diagnostic indicator (7). Anti-CA I and anti-CA II antibodies (aCAIab and aCAIIab) have recently been isolated from patients with systemic lupus erythematosus (8)(9), polymyositis and systemic sclerosis (9), endometriosis(10)(11), Sjögren syndrome (8)(9)(12)(13), idiopathic chronic pancreatitis (13)(14), primary biliary cirrhosis (PBC) (12)(13)(15)(16), and autoimmune cholangitis (15).

It has recently been hypothesized that all of these diseases (many of which can occur concomitantly) may have a common pathogenetic mechanism based on autoimmune reactions against a common antigen. According to this hypothesis, it seems that highly active CA isoenzymes (cytosolic CA II and membrane-bound CA IV) are particularly involved, because CA plays an important role in such biochemical processes as tissue hydration and secretory activities. In some cases, the preincubation of CA with specific inhibitors has blocked its antibody interactions, suggesting that the site of the immunologic reaction may involve the active site of the enzyme (9).

In patients with PBC, anti-CA antibodies are often associated with the presence of anti-mitochondrial antibodies, particularly anti-pyruvate dehydrogenase (17)(18)(19), which is the main diagnostic marker of the disease (20)(21). However, anti-CA antibodies have also been detected . . . [Full Text of this Article]

The following articles in journals at HighWire Press have cited this article:

				P Invernizzi, C Selmi, M Zuin, and M Podda Lack of serum antibodies to membrane bound carbonic anhydrase IV in patients with primary biliary cirrhosis Gut, November 1, 2005; 54(11): 1665 - 1665. [Full Text] [PDF]