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Clinical Chemistry 49: 1421-1422, 2003; 10.1373/49.8.1421
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(Clinical Chemistry. 2003;49:1421-1422.)
© 2003 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Method Evaluation for Total ß-Human Chorionic Gonadotropin Using Urine and the ADVIA Centaur

Anna M. Halldorsdottir1, Mary O. Carayannopoulos1, Mary Scrivner2 and Ann M. Gronowski1,a

1 Department of Pathology, and Immunology, Division of Laboratory Medicine, Washington University, School of Medicine, 660 South Euclid Ave., Box 8118, St. Louis, MO 63110

2 Barnes-Jewish Hospital, St. Louis, MO 63110

aAuthor for correspondence. Fax 314-362-1461; e-mail gronowski@pathology.wustl.edu.

The first 20% of the full text of this article appears below.


To the Editor:

We recently described the use of a quantitative serum human chorionic gonadotropin (hCG) assay with urine samples (1) . Quantitative urine hCG assays are important in validations of point-of-care qualitative hCG tests and in cases of suspected false-positive quantitative serum hCG results because of heterophilic antibodies (2)(3). Here, we report our study of the ADVIA Centaur® (Bayer Corporation) total-hCG (ThCG) serum assay with urine.

Recovery of hCG (US Pharmaco-peia) added to urine was >100% at all concentrations (Table 1 ). At concentrations <=200 IU/L, recovery was >130%. Urine hCG measurements <=200 IU/L were linear but were not parallel to expected amounts. For . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
A. M. Ferguson, B. Ford, and A. M. Gronowski
Method Validation for Cerebral Spinal Fluid Human Chorionic Gonadotropin Measurement with the Advia Centaur(R)
Clin. Chem., August 1, 2008; 54(8): 1408 - 1409.
[Full Text] [PDF]


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