Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 49: 1544-1546, 2003; 10.1373/49.9.1544
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Web of Science (3)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ponthieux, A.
Right arrow Articles by Visvikis, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ponthieux, A.
Right arrow Articles by Visvikis, S.
Related Collections
Right arrow General Clinical Chemistry
Right arrow Proteomics and Protein Markers
Right arrow Lipids, Lipoproteins, and Cardiovascular Risk Factors
(Clinical Chemistry. 2003;49:1544-1546.)
© 2003 American Association for Clinical Chemistry, Inc.

Technical Briefs

Age- and Sex-related Reference Values for Serum Adhesion Molecule Concentrations in Healthy Individuals: Intercellular Adhesion Molecule-1 and E-, P-, and L-Selectin

Anne Ponthieux1, Bernard Herbeth1, Suzanne Droesch1, Daniel Lambert1 and Sophie Visvikis1,a

1 Institut National de la Santé et de la Recherche Médicale (INSERM) U 525, 30 rue Lionnois, 54000 Nancy, France, and Centre de Médecine Préventive, 2 rue du Doyen Jacques Parisot, 54500 Vandoeuvre-lès-Nancy, France

aaddress correspondence to this author at: INSERM Unité 525, 30 rue Lionnois, 54000 Nancy, France; fax 33-03-83-32-13-22, e-mail Sophie.visvikis@cmp.u-nancy.fr

The first 20% of the full text of this article appears below.

Intercellular adhesion molecule-1 (ICAM-1) and E-, P-, and L-selectin are cellular adhesion molecules involved in the recruitment of leukocytes on the activated vessel wall during inflammation (1) and play an important role in the early stages of atherosclerosis and its complications (2). Thus, the measurement of soluble adhesion molecules in serum may have diagnostic relevance in many inflammatory diseases (3). A profile of soluble adhesion molecule concentrations may allow better therapeutic decisions in inflammatory and autoimmune disorders, infection, cancer, and cardiovascular pathologies and may also aid in the prediction of cardiovascular events (4)(5). However, the use of these markers in clinical practice depends critically on knowledge of their reference values.

The purpose of the present study was to establish age- and sex-specific reference intervals for serum concentrations of soluble ICAM-1 and E-, P-, and L-selectin in healthy children (4–17 years) and adults (18–55 years).

Blood samples were taken from healthy individuals (157 boys and 146 girls 4–17 years of age and 245 men and 250 women 18–55 years of age) who were members of the Stanislas cohort (6). Participants were of French origin (Vosges and Meurthe et Moselle); free from serious and/or chronic illnesses, especially cardiovascular, hepatic, or renal diseases; and were not on treatment with lipid-lowering drugs. Volunteers with aspartate aminotransferase, alanine aminotransferase, or {gamma}-glutamyltransferase activities >200 U/L, apolipoprotein E concentrations >200 mg/L, orosomucoid or haptoglobin concentrations >3 g/L, . . . [Full Text of this Article]






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2003 by the American Association for Clinical Chemistry.