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Clinical Chemistry 49: 1552-1554, 2003; 10.1373/49.9.1552
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(Clinical Chemistry. 2003;49:1552-1554.)
© 2003 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Natriuretic Peptides (NPs): Automated Electrochemiluminescent Immunoassay for N-Terminal pro-BNP Compared with IRMAs for ANP and BNP in Heart Failure Patients and Healthy Individuals

Concetta Prontera1, Michele Emdin1, Gian Carlo Zucchelli1, Andrea Ripoli1, Claudio Passino1 and Aldo Clerico1,a

1 Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Località San Cataldo, Via Moruzzi, 1, 56100 Pisa, Italy

aAuthor for correspondence. Fax 39-050-3152116 or 39-0585-493601; e-mail clerico@ifc.cnr.it.

The first 20% of the full text of this article appears below.


To the Editor:

We evaluated the performance and diagnostic accuracy of an electrochemiluminescence immunoassay (ECLIA) method for N-terminal pro-B-type natriuretic peptide (NT-proBNP) in healthy persons and in patients with cardiac disease, and then compared the results obtained with the ECLIA method with results from IRMA methods for BNP and atrial natriuretic peptide (ANP).

We studied 58 healthy individuals [mean (SD) age, 58 (8) years; 19 women and 39 men] and 148 consecutive patients [mean age, 64 (13) years; range, 20–80 years; 47 women and 101 men] with cardiomyopathy, admitted to the Department of Cardiovascular Medicine of our Institute. The study was done from November 2001 to October 2002. All healthy participants were nonobese, normotensive, and free from acute diseases, and all denied the use of any drug during the 4 weeks before the study. All had normal values for the main plasma indices and nonpathologic erythrocyte and leukocyte counts and urine analysis. In all of the participants, a complete cardiologic examination, including electrocardiogram and echocardiographic investigation (left ventricular ejection fraction >55%), was performed; in patients >50 years of age, an effort stress test was performed . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


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 Clin. Chem.Home page
C. Vassalle, M. G. Andreassi, C. Prontera, M. Fontana, L. Zyw, C. Passino, and M. Emdin
Influence of ScaI and Natriuretic Peptide (NP) Clearance Receptor Polymorphisms of the NP System on NP Concentration in Chronic Heart Failure
Clin. Chem., November 1, 2007; 53(11): 1886 - 1890.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
T. Mueller, A. Gegenhuber, B. Dieplinger, W. Poelz, and M. Haltmayer
Capability of B-Type Natriuretic Peptide (BNP) and Amino-Terminal proBNP as Indicators of Cardiac Structural Disease in Asymptomatic Patients with Systemic Arterial Hypertension
Clin. Chem., December 1, 2005; 51(12): 2245 - 2251.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
A. Clerico, C. Prontera, M. Emdin, C. Passino, S. Storti, R. Poletti, L. Zyw, and G. C. Zucchelli
Analytical Performance and Diagnostic Accuracy of Immunometric Assays for the Measurement of Plasma B-Type Natriuretic Peptide (BNP) and N-Terminal proBNP
Clin. Chem., February 1, 2005; 51(2): 445 - 447.
[Full Text] [PDF]

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 Clin. Chem.Home page
A. Hammerer-Lercher, W. Ludwig, G. Falkensammer, S. Muller, E. Neubauer, B. Puschendorf, O. Pachinger, and J. Mair
Natriuretic Peptides as Markers of Mild Forms of Left Ventricular Dysfunction: Effects of Assays on Diagnostic Performance of Markers
Clin. Chem., July 1, 2004; 50(7): 1174 - 1183.
[Abstract] [Full Text] [PDF]

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 Clin. Chem.Home page
A. Clerico and M. Emdin
Diagnostic Accuracy and Prognostic Relevance of the Measurement of Cardiac Natriuretic Peptides: A Review
Clin. Chem., January 1, 2004; 50(1): 33 - 50.
[Abstract] [Full Text] [PDF]


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