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Clinical Chemistry 49: 1560-1562, 2003; 10.1373/49.9.1560
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(Clinical Chemistry. 2003;49:1560-1562.)
© 2003 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Stability of N-Terminal Pro-Brain Natriuretic Peptide after Storage Frozen for One Year and after Multiple Freeze-Thaw Cycles

William L. Nowatzke1,a and Thomas G. Cole1

1 Washington University School of Medicine, Department of Medicine, Box 8046, 660 South Euclid Ave., St. Louis, MO 63110

aAuthor for correspondence. Fax 314-362-4782; e-mail bnowatzk@im.wustl.edu.

The first 20% of the full text of this article appears below.


To the Editor:

Cardiac natriuretic peptides are of interest for their potential role in assisting in the diagnosis, prognosis, and monitoring of left ventricular dysfunction and congestive heart failure (1). An electrochemiluminescence immunoassay for the measurement of N-terminal pro-brain natriuretic peptide (NT-proBNP) on the Elecsys® immunoassay analyzer platform (Roche Diagnostics Corporation) has recently received Food and Drug Administration clearance to aid in the diagnosis of congestive heart failure (2). We report here on the stability of the NT-proBNP analyte when measured with the Roche Diagnostic NT-proBNP assay after specimen storage at -80 °C for longer than 1 year and after five freeze-thaw (-80 and 22 °C) cycles.

Twenty-five samples were collected from healthy and heart failure clinic adult volunteers under informed consent according to the policies of the Washington University School of Medicine’s Institutional Review Board. All glass collection tubes were from Becton Dickinson. Lithium-heparin plasma (prod. no. . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Ann Clin BiochemHome page
B Cauliez, J Guignery, S Marinier, I Mariau, and A Lavoinne
Two-year stability of NT-proBNP in frozen samples using the Roche Elecsys system
Ann Clin Biochem, May 1, 2008; 45(3): 318 - 319.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
F. S. Apple, M. Panteghini, J. Ravkilde, J. Mair, A. H.B. Wu, J. Tate, F. Pagani, R. H. Christenson, A. S. Jaffe, and on Behalf of the Committee on Standardization of M
Quality Specifications for B-Type Natriuretic Peptide Assays
Clin. Chem., March 1, 2005; 51(3): 486 - 493.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
K.-M. Hermann-Arnhof, U. Hanusch-Enserer, T. Kaestenbauer, T. Publig, A. Dunky, H. R. Rosen, R. Prager, and U. Koller
N-Terminal Pro-B-Type Natriuretic Peptide as an Indicator of Possible Cardiovascular Disease in Severely Obese Individuals: Comparison with Patients in Different Stages of Heart Failure
Clin. Chem., January 1, 2005; 51(1): 138 - 143.
[Abstract] [Full Text] [PDF]


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