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Fifty Years of Clinical Chemistry

¹ Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908
² Laboratory of Molecular Diagnostics, Wadsworth Center for Laboratories and Research, New York State Department of Health, Department of Biomedical Sciences, State University of New York at Albany, Albany, NY 12201-0509

^aAuthor for correspondence. Fax 434-979-7599; e-mail dbruns@clinchem.aacc.org.

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This issue marks the start of this Journal’s 50th year of continuous publication. A look back at our first volumes shows how much has changed over the past five decades and reveals interests that have stayed the same. In 1955, Clinical Chemistry was published bimonthly and comprised just over 400 pages. In the early years, articles describing new methods or new investigations were less common than now, with reviews and meeting reports filling many of the pages. Many of the papers, however, were devoted to general topics still very much of interest to current readers—lipids, endocrinology, protein markers, and advances in methodology.

As with any scientific journal, the contents of Clinical Chemistry mirror activities in the field and play an important role in defining the scope of the field. Readers comparing the contents of the current issue with those of the first volume will readily grasp the evolution of clinical chemistry into new areas. Papers on molecular diagnostics, genomics, and proteomics now fill a major portion of our pages. In this post-genomic age, it is easy to forget that the structure of DNA was elucidated just a few months before the founding of this Journal. Although clinical chemistry and laboratory medicine have a foundation dating back centuries, they are relatively young as disciplines. Only through biomedical research occurring at the time of this Journal’s founding were modern clinical laboratories established (1). This Journal has grown with those laboratories, and it has expanded the definition of "clinical chemistry".

Today’s medical decisions have a greater reliance on laboratory measurements than they did just a decade ago, much . . . [Full Text of this Article]

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