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Clinical Chemistry 50: 1861-1870, 2004. First published August 12, 2004; 10.1373/clinchem.2004.038976
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Right arrow Lipids, Lipoproteins, and Cardiovascular Risk Factors
(Clinical Chemistry. 2004;50:1861-1870.)
© 2004 American Association for Clinical Chemistry, Inc.

Histories

Clinical Chemistry Journal Has Contributed to Progress in Lipid and Lipoprotein Testing for Fifty Years

Nader Rifai1,a, Gerald R. Cooper2, W. Virgil Brown3, William Friedewald4, Richard J. Havel5, Gary L. Myers2 and G. Russell Warnick6

1 Children’s Hospital, Department of Laboratory Medicine, Boston, MA.
2 Centers for Disease Control and Prevention, Chalblee, GA.
3 Department of Medicine, Emory University, Atlanta, GA.
4 Columbia University, New York, NY.
5 University of California San Francisco, San Francisco, CA.
6 Pacific Biometrics Research Foundation, Issaquah, WA.

aAddress correspondence to this author at: Children’s Hospital, Department of Laboratory Medicine, Boston, MA 02115. E-mail nader.rifai@tch.harvard.edu.

The first 300 words of the full text of this article appear below.

The journal Clinical Chemistry has played a major role in facilitating the progress that has occurred in lipid and lipoprotein testing over the past 50 years. In celebration of the 50th anniversary of the Journal, this Special Report highlights five selected areas of highly significant accomplishments during the past 50 years contributed by key researchers, some whose careers have spanned the entire history of modern lipid analysis and research.

An overview of the history of lipid analysis from nonspecific strong acid methods to modern enzymatic assays, fully integrated lipoprotein methods, and the remarkable instrumentation developed by industry is presented by G. Russell Warnick.

Dr. Bill Friedewald, whose name is associated with the widely recognized calculation of LDL-cholesterol (1), will relate the genesis of this important development. His 1972 report in Clinical Chemistry (1) has become the most cited ever in the Journal, with more than 6000 citations.

Dr. Richard Havel developed an ultracentrifugal method in 1955 that continues to be the common citation for preparative isolation of the lipoproteins (2). The Lipid Research Clinic (LRC)1 laboratories, in addition to assaying for cholesterol and triglycerides, separated VLDL from the bottom layer of LDL and HDL for HDL analyses by ultracentrifugation, following this method. Dr. Havel, who is still active in lipid research, provides his views on the history of the lipoproteins and separation methodology.

Drs. Gerald Cooper and Gary Myers present the story of how the CDC/National Heart Lung and Blood Institute (CDC-NHLBI) Lipid Standardization Program was developed over a period of nearly 50 years. The LRC program also focused attention on the need for standardization of lipid and lipoprotein measurements. Dr. Cooper of the CDC, one of the co-authors of the standardization article (3), has been a leader in the standardization field . . . [Full Text of this Article]


A Partner in Improving Lipid Analysis: From Acids to Enzymes


Comments on the Development of the Friedewald Equation


Separation of Lipoproteins by Ultracentrifugation


Cholesterol Standardization: Leading the Way to Laboratory Improvement

comments from dr. cooper
comments from dr. myers

Clinical Impact of the Lipid Research Clinics Program






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Copyright © 2004 by the American Association for Clinical Chemistry.