Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 50: 1881-1883, 2004; 10.1373/clinchem.2004.040634
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Willems, H. P.J.
Right arrow Articles by Blom, H. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Willems, H. P.J.
Right arrow Articles by Blom, H. J.
Related Collections
Right arrow Lipids, Lipoproteins, and Cardiovascular Risk Factors
Right arrow Automation and Analytical Techniques
(Clinical Chemistry. 2004;50:1881-1883.)
© 2004 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Measurement of Total Homocysteine Concentrations in Acidic Citrate- and EDTA-Containing Tubes by Different Methods

Huub P.J. Willems1,a, Martin den Heijer2, Jan Lindemans3, Henriette W.A. Berenschot4, Wim B.J. Gerrits1, Gerard M.J. Bos5 and Henk J. Blom6

1 Department of Hematology, Leyenburg Hospital, The Hague, The Netherlands
2 Departments of Endocrinology and Epidemiology, and Biostatistics and6 Laboratory of Pediatrics and Neurology, University Medical Center Nijmegen, Nijmegen, The Netherlands
3 Laboratory of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands
4 Department of Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands
5 Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands

aAddress correspondence to this author at: Department of Internal Medicine, Máxima Medical Center Eindhoven, PO Box 90052, 5600 PD Eindhoven, The Netherlands. Fax 31-40-245-0385; e-mail hpj.willems@niv.medonline.nl.

The first 20% of the full text of this article appears below.


To the Editor:

Blood collection for total homocysteine (tHcy) measurements is usually done in tubes containing EDTA as anticoagulant. At room temperature there is an increase in tHcy in whole blood (1)(2); therefore, tubes must be put on melting ice immediately and centrifuged within 1 or 2 h. Large epidemiologic studies, however, require blood collection techniques that are easily applicable in a field setting. We found that citrate with a low pH (pH 4.3; pH ~5.9 after mixing with blood) stabilizes tHcy in whole blood for 6 h when the blood is stored at room temperature (1), but that measured absolute tHcy concentrations differ in acidic citrate and EDTA.

In this study we investigated the differences . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
U. Hubner, H. Schorr, R. Eckert, J. Geisel, and W. Herrmann
Stability of Plasma Homocysteine, S-Adenosylmethionine, and S-Adenosylhomocysteine in EDTA, Acidic Citrate, and PrimavetteTM Collection Tubes
Clin. Chem., December 1, 2007; 53(12): 2217 - 2218.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the American Association for Clinical Chemistry.