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Clinical Chemistry 50: 780-782, 2004; 10.1373/clinchem.2003.029066
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(Clinical Chemistry. 2004;50:780-782.)
© 2004 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Urinary Iodine Analysis: An Alternative Method for Digestion of Urine Samples

Sahar Fallouch2, Pierre-Jean Lejeune1, Jocelyne Barbaria1, Pierre Carayon1 and Bernard Mallet1,a

1 INSERM U555, Faculté de Médecine and Hôpital Universitaire de la Timone, Marseille, France
2 University of Medicine of Damascus, Damascus, Syria

aAuthor for correspondence. E-mail bernard.mallet@medecine.univ-mrs.fr.

The first 20% of the full text of this article appears below.


To the Editor:

Iodide plays a central role in thyroid physiology, and iodine compounds are essential for normal vertebrate growth and development. Useful information about the iodine nutritional status of a population can be obtained by measuring urinary iodine to estimate the prevalence of iodine deficiency disorders. Several methods for measuring urinary iodine are currently available [for a review, see Ref. (1)]: most of these involve the Sandell–Kolthoff reaction (2), which is based on a colorimetric ceric–arsenic assay. However, these methods are susceptible to several problems: e.g., various contaminants can cause the reduction of cerium(IV), or pigments or drug metabolites in the urine can increase the natural yellow color of the urine, leading to false-negative results. The digestion of urine samples, which is the first step in all of the methods based on the Sandell–Kolthoff reaction, is therefore crucial.

In this study, we tested three digestion methods on 200 urine samples from patients hospitalized at the La Timone University Hospital: the conventional chloric acid method (1); an acid ammonium persulfate method (3)(4); and a method involving a HNO3–HCl mixture. For the latter method, the digestion was performed by mixing 3 mL of 14.3 mol/L HNO3 with 2 mL of 12.1 mol/L HCl just before use. Urine samples . . . [Full Text of this Article]






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