Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 50: 786-787, 2004; 10.1373/clinchem.2003.025924
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sodi, R.
Right arrow Articles by Stott, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sodi, R.
Right arrow Articles by Stott, A.
Related Collections
Right arrow Proteomics and Protein Markers
Right arrow Lipids, Lipoproteins, and Cardiovascular Risk Factors
(Clinical Chemistry. 2004;50:786-787.)
© 2004 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Time for Troponin T? Implications from Newly Elucidated Structure

Ravinder Sodi1,a, Simon Darn1 and Anthony Stott1

1 Department of Clinical Chemistry, Royal Liverpool and Broadgreen, University Hospitals, Prescot Street, Liverpool L7 8XP, United Kingdom

aAuthor for correspondence. Fax 44-0151-706-4250; e-mail ravsodi@yahoo.com.

The first 20% of the full text of this article appears below.


To the Editor:

The recent publication of the structure of the core domain of the troponin complex in Nature (1) has prompted us to ask: "What is the cardiac troponin T (cTnT) assay actually measuring?"

Roche Diagnostics Corporation has developed an electrochemiluminescence assay for cTnT (Roche E170), which detects free cTnT and binary/ternary troponin complexes released into the serum after a myocardial infarction (2). This assay uses two antibodies (M7 and M11.7) that recognize two specific epitopes (residues 125–131 and 136–147, respectively). The cTnT protein itself consists of 288 amino acids. From the study by Takeda et al. (1), we have been able to ascertain that the amino acid sequences of . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
M. N. Fahie-Wilson, D. J. Carmichael, M. P. Delaney, P. E. Stevens, E. M. Hall, and E. J. Lamb
Cardiac Troponin T Circulates in the Free, Intact Form in Patients with Kidney Failure
Clin. Chem., March 1, 2006; 52(3): 414 - 420.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the American Association for Clinical Chemistry.