Clinical Chemistry
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Clinical Chemistry 50: 973-974, 2004; 10.1373/clinchem.2004.031591
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(Clinical Chemistry. 2004;50:973-974.)
© 2004 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Preeclampsia and the C282Y Mutation in the Hemochromatosis (HFE) Gene

Ingrid P. Senden1, Christianne J.M. de Groot1, Eric A.P. Steegers1, Rogier M. Bertina2 and Dorine W. Swinkels3,a

1 Department of Obstetrics, and Gynecology, Erasmus University Medical Center, Rotterdam, The Netherlands2 Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands3 Department of Clinical Chemistry, University Medical Center Nijmegen, Nijmegen, The Netherlands

aAddress correspondence to this author at: Department of Clinical Chemistry 564, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail D.Swinkels@akc.umcn.nl.

The first 20% of the full text of this article appears below.


To the Editor:

The hemochromatosis (HFE) gene encodes the HFE protein, a transmembrane glycoprotein that is implicated in the modulation of iron uptake from the diet (1). The C282Y mutation in this gene is known to be associated with moderately increased serum iron indices. Recently, several studies have described an association between increased maternal iron status and an unfavorable pregnancy outcome (2)(3). Preeclampsia is one of the most common pregnancy-related syndromes as well as a major cause of fetal and maternal morbidity and mortality. Preeclampsia is defined by de novo hypertension and proteinuria in pregnancy. The etiology of preeclampsia is complex and not fully understood, but abnormal . . . [Full Text of this Article]






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Copyright © 2004 by the American Association for Clinical Chemistry.