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Clinical Chemistry 50: 1106-1107, 2004; 10.1373/clinchem.2004.033589
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(Clinical Chemistry. 2004;50:1106-1107.)
© 2004 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Bicarbonate Interference with Chloride-Ion-Selective Electrodes

Goce Dimeskia and Alan E. Clague

1 Department of Chemical Pathology, Queensland Health Pathology Service, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia

aAuthor for correspondence. Fax 61-7-3240-5082; e-mail Goce_Dimeski@health.qld.gov.au.

The first 20% of the full text of this article appears below.


To the Editor:

Plasma chloride is of value in the assessment of acid/base and electrolyte abnormalities. It is a component in calculation of both the anion gap and strong ion differences. The analytical method used extensively today, particularly in high-throughput analyzers, involves an ion-selective electrode incorporating a quaternary nitrogen compound. This has superseded amperometric titration with silver electrodes, which is not amenable to high-throughput or multianalyte instrumentation, and mercuric thiocyanate-based colorimetric methods, which require disposal of a toxic waste product.

In 1986 and 1991, two reports (1)(2) were published that documented marked positive interference by bicarbonate on plasma chloride analyses performed by Hitachi 705 and 717 analyzers. No further reports have been published since then. We suspected that similar problems might be occurring with the Dade Dimension RxL analyzer because of the high frequency of negative anion-gap calculations in samples from patients with . . . [Full Text of this Article]




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The Effect of Albumin Concentration on Plasma Sodium and Chloride Measurements in Critically Ill Patients
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[Abstract] [Full Text] [PDF]


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