Clinical Chemistry
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Clinical Chemistry 50: 1272-1273, 2004; 10.1373/clinchem.2004.033019
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(Clinical Chemistry. 2004;50:1272-1273.)
© 2004 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Early Detection of the Selectivity Loss of the Cobas Integra Analyzer Chloride Ion-Selective Electrode

Siegmund L. Brauna, Kathrin Ciolek and Wolfgang Vogt

1 Institut für Laboratoriumsmedizin, Deutsches Herzzentrum München, Klinik an der TU München, Munich, Germany

aAddress correspondence to this author at: Institut für Laboratoriumsmedizin, Deutsches Herzzentrum München, Klinik an der TU München, Lazarettstrasse 36, D-80636 Munich, Germany. Fax 49-89-1218-1013; e-mail braun@dhm.mhn.de.

The first 20% of the full text of this article appears below.


To the Editor:

Electrolyte measurements predominantly use ion-selective electrodes (ISEs) for sodium, potassium, and chloride. In contrast to the reliability of the sodium and potassium electrodes, erroneous chloride ISE values have occasionally been reported (1)(2)(3). We recently observed an increasing number of falsely high chloride concentrations in patient plasma samples. These results appeared at unpredictable intervals after replacement of the electrode on a Cobas Integra analyzer (Roche Diagnostics). Repeat analyses with a coulometric method yielded significantly lower results.

The falsely high values appeared not to have been caused by a general low selectivity of the chloride electrode, which responds to other ions such as iodide, thiocyanate, nitrate, and bromide (1)(2)(3). More likely was a time-dependent deterioration of the chloride electrode, . . . [Full Text of this Article]






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Copyright © 2004 by the American Association for Clinical Chemistry.