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Clinical Chemistry 51: 1768-1769, 2005; 10.1373/clinchem.2005.055483
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(Clinical Chemistry. 2005;51:1768-1769.)
© 2005 American Association for Clinical Chemistry, Inc.

Editorials

Toward "Serolomics": Papillomavirus Serology Is Taking a Technologic Lead in High-Throughput Multiplexed Antibody Analysis

Joakim Dillner

Department of Medical Microbiology, Lund University, Malmö, Sweden

aAddress for correspondence: Department of Medical Microbiology, Lund University, Malmö University Hospital, Malmö SE-20502, Sweden.

The first 20% of the full text of this article appears below.

The report by Waterboer et al. (1) in this issue represents one of the most thorough attempts to develop a high-throughput system for simultaneous analysis of antibodies against a large number of antigens. High-throughput assays, notably through various types of arrays, are increasingly important research tools in modern molecular medicine, but almost all the technologic development has been directed toward the analysis of DNA, RNA, and proteins (2), with more limited technologic progress in the field of serology. Will we see multiplexed antibody analysis, "serolomics", arising as a new research field alongside genomics, RNomics, and proteomics?

Measurements of groups of antibodies can have application in multiple areas of medicine. Analysis of a broad spectrum of autoantibodies is increasingly used in predictive diagnostics of autoimmune diseases (3), and autoantibodies against oncogene products are being studied in predictive oncology (4). The most interesting medical application, however, would be to rapidly assay the spectrum of microbiological agents to which a person has been exposed because past infections can be highly predictive of the risk of future diseases. Important examples include cardiovascular diseases, allergies, and cancer. Exposure to infections accounts for ~17% of human cancers, with human papillomavirus (HPV) being one of the most important . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


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D. A.M. Heideman, T. Waterboer, M. Pawlita, P. Delis-van Diemen, I. Nindl, J. A. Leijte, J. M.G. Bonfrer, S. Horenblas, C. J.L.M. Meijer, and P. J.F. Snijders
Human Papillomavirus-16 Is the Predominant Type Etiologically Involved in Penile Squamous Cell Carcinoma
J. Clin. Oncol., October 10, 2007; 25(29): 4550 - 4556.
[Abstract] [Full Text] [PDF]


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