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Clinical Chemistry 51: 2001-2002, 2005; 10.1373/clinchem.2005.056382
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(Clinical Chemistry. 2005;51:2001-2002.)
© 2005 American Association for Clinical Chemistry, Inc.

Editorials

Diagnostic Biomarkers for Stroke: A Stroke Neurologist’s Perspective

Michael D. Hill

Univeristy of Calgary, Foothills Medical Centre, Rm 1242A, Calgary, Alberta, T2N 2T9 Canada

The first 20% of the full text of this article appears below.

Since 2003, four articles on stroke biomarkers as potential diagnostic tests have been published in Clinical Chemistry (1)(2)(3)(4). Each has described an initial foray into attempting to find a holy grail in clinical stroke—a blood test for stroke—and each has provided early exciting results that suggest that we may yet welcome a new era of stroke diagnostics into the clinical realm.

Human stroke is remarkably heterogeneous. Stroke varies widely in severity with a majority of strokes being mild. Stroke comes in 3 major types. In North America and Europe, ischemic stroke comprises 85% of all strokes, intracerebral hemorrhage 8%, and subarachnoid hemorrhage 7%. These ratios differ in Asia with up to 30% of strokes occurring as intracerebral hemorrhages. For the neurologist, stroke is relatively easy to diagnose clinically. It is the most common cause of a sudden acute neurologic deficit in both adults and children. Imaging is the mainstay of identifying stroke type because it is not possible to distinguish ischemia from hemorrhage reliably on clinical grounds alone.

A brain computed tomographic scan rules in an intracerebral hemorrhage or subarachnoid hemorrhage and in many cases rules . . . [Full Text of this Article]






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