Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 51: 2422-2423, 2005; 10.1373/clinchem.2005.060392
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kricka, L. J.
Right arrow Articles by Fontanilla, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kricka, L. J.
Right arrow Articles by Fontanilla, R.
Related Collections
Right arrow Laboratory Management
Right arrow General Clinical Chemistry
Right arrow Endocrinology and Metabolism
(Clinical Chemistry. 2005;51:2422-2423.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Processing Controls in Blood Collection Tubes Reveals Interference

Larry J. Krickaa, Jason Y. Park, Marilyn B. Senior and Rodelia Fontanilla

Department of Pathology, and Laboratory Medicine, Hospital of the, University of Pennsylvania, Philadelphia, PA

aAddress correspondence to this author at: Hospital of the University of Pennsylvania, Department of Pathology and Laboratory Medicine, 3400 Spruce St., Philadelphia, PA 19104-4283. Fax 215-662-7529; e-mail kricka@mail.med.upenn.edu.

The first 20% of the full text of this article appears below.


To the Editor:

Central tenets of quality control (QC) and quality assurance are that (a) controls should be handled by the regular staff, and (b) they should be treated the same way as an equivalent patient specimen. This is not always adhered to in routine practice, and recent problems with blood collection tubes underline this point (1)(2)(3)(4). Collection of blood in certain batches of Vacutainer® SST tubes was associated with errors in some immunoassays on certain immunoassay platforms [e.g., biases of 20% to 30% for total thyroxine (T4), total triiodothyronine (T3), and cortisol and –15% to 20% for follicle-stimulating hormone (FSH)]. These errors have been attributed to contamination of samples with surfactants that are used to coat the tubes; the surfactant can release reagent antibodies from some solid-phase materials used in immunoassay methods (5)(6).

Blood specimens for testing are removed through a metal needle into a blood collection tube. The tube and its contents are centrifuged to isolate serum, and the serum is either sampled directly from this tube . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
A. K. Stankovic and G. Parmar
Assay interferences from blood collection tubes: a cautionary note.
Clin. Chem., August 1, 2006; 52(8): 1627 - 1628.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2005 by the American Association for Clinical Chemistry.