Clinical Chemistry
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Clinical Chemistry 51: 1305, 2005; 10.1373/clinchem.2005.051599
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(Clinical Chemistry. 2005;51:1305.)
© 2005 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Identification of Hemoglobin Variants by HPLC - Reply

Alla JoutovskyR1, Joan Hadzi-NesicR1 and Michael A. NardiR2,a

Departments ofR1 Pathology and R2 Pediatrics, New York University School of Medicine, and Bellevue Hospital Center, New York, NY 10016

aAuthor for correspondence.

The first 20% of the full text of this article appears below.


To the Editor:

We would like to thank Hoyer and Scheidt for their interest in our report (1), and we wish to comment on points raised in their letter.

Our report detailed the experience of a prospective study of more than 60 000 samples in a clinical laboratory, rather than a reference/research laboratory, with its use of HPLC. An algorithm involving retention time, percentage of hemoglobin fraction, and peak characteristics was proposed to aid in the processing of future samples. This algorithm has now been tested in more than 26 000 samples. Preliminary results have been presented (2), and a final manuscript is in preparation.

Hoyer and Scheidt state that the retention time can change with different lots of columns and reagents on the Variant system, which has also been reported elsewhere (3), and they give examples of . . . [Full Text of this Article]






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Copyright © 2005 by the American Association for Clinical Chemistry.