HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by van der Zee, P. M. Articles by Fischer, J. C. Search for Related Content PubMed PubMed Citation Articles by van der Zee, P. M. Articles by Fischer, J. C. Related Collections Proteomics and Protein Markers Lipids, Lipoproteins, and Cardiovascular Risk Factors

Ischemia-Modified Albumin Measurements in Symptom-Limited Exercise Myocardial Perfusion Scintigraphy Reflect Serum Albumin Concentrations but Not Myocardial Ischemia

Departments of¹ Cardiology, ² Nuclear Medicine, and³ Clinical Chemistry, Academic Medical Center, Amsterdam, The Netherlands;

^aaddress correspondence to this author at: Academic Medical Center, Department of Cardiology, Room B2-223, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; fax 31-20-6962609, e-mail p.m.vanderzee@amc.uva.nl

The first 20% of the full text of this article appears below.

The albumin cobalt-binding test (Ischemia Technologies), which measures the concentration of ischemia-modified albumin (IMA), has been cleared by the US Food and Drug Administration for use as a rule-out marker for acute myocardial ischemia (1). The test is based on the reduced capacity of human albumin to bind cobalt as a result of structural changes in the NH₂ terminus of the albumin molecule in conditions of myocardial ischemia (2)(3). Moreover, IMA concentrations correlated with disease severity in systemic sclerosis (4), and an exercise-induced decrease in IMA concentrations correlated with the ankle-brachial index in patients with peripheral artery sclerosis (5). Little is known, however, about the relationship between exercise-induced myocardial ischemia, albumin kinetics, and IMA kinetics. We therefore investigated this relationship in 38 patients with chest complaints and suspected coronary artery disease who were undergoing symptom-limited exercise myocardial perfusion scintigraphy. Myocardial perfusion scintigraphy was performed according to the guidelines of the American Society of Nuclear Cardiology (6), with a 2-day stress/rest protocol. A dose of 500 MBq of [^99mTc]-Tetrofosmin was administered at rest and at peak exercise. Electrocardiogram-gated single photon emission tomography imaging was started 45 min to 1 h after the administration of radioactive-labeled tracer. All patients exercised on a bicycle ergometer with a starting workload of 50 W, increasing every 2 min by 25 W. Endpoints for exercise included achievement of at least 85% of . . . [Full Text of this Article]

The following articles in journals at HighWire Press have cited this article:

				H Demir, B C Topkaya, A R Erbay, M Dogan, and D Yucel Ischaemia-modified albumin elevation after percutaneous coronary intervention reflects albumin concentration rather than ischaemia Ann Clin Biochem, July 1, 2009; 46(4): 327 - 331. [Abstract] [Full Text] [PDF]

				P O Collinson and D C Gaze Ischaemia-modified albumin: clinical utility and pitfalls in measurement J. Clin. Pathol., September 1, 2008; 61(9): 1025 - 1028. [Full Text] [PDF]

				E. Sbarouni, P. Georgiadou, G. N. Theodorakis, and D. Th. Kremastinos Reply J. Am. Coll. Cardiol., June 19, 2007; 49(24): 2376 - 2377. [Full Text] [PDF]

				E. Sbarouni, P. Georgiadou, G. N. Theodorakis, and D. Th. Kremastinos Ischemia-Modified Albumin in Relation to Exercise Stress Testing J. Am. Coll. Cardiol., December 19, 2006; 48(12): 2482 - 2484. [Abstract] [Full Text] [PDF]