Clinical Chemistry
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 53: 153-154, 2007; 10.1373/clinchem.2006.081471
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brinkman, J. W.
Right arrow Articles by Bakker, S. J.L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brinkman, J. W.
Right arrow Articles by Bakker, S. J.L.
Related Collections
Right arrow General Clinical Chemistry
Right arrow Proteomics and Protein Markers
(Clinical Chemistry. 2007;53:153-154.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Prolonged Frozen Storage of Urine Reduces the Value of Albuminuria for Mortality Prediction

Jacoline W. Brinkmana, Dick de Zeeuw1, Ronald T. Gansevoort2, Jacko J. Duker1, Ido P. Kema3, Paul E. de Jong1 and Stephan J.L. Bakker1

Departments of1 Clinical Pharmacology2 Internal Medicine3 Pathology and Laboratory Medicine, University of Groningen, University Medical Center, Groningen, The Netherlands

aAddress correspondence to this author at: Department of Clinical Pharmacology, University of Groningen and University Medical Center Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands. Fax 31-50-363-2812; e-mail j.w.brinkman@int.umcg.nl.

The first 20% of the full text of this article appears below.


To the Editor:

Albuminuria is increasingly recognized as a cardiovascular risk factor in patients with diabetes and in the general population. Cardiovascular disease risk increases continuously with increasing urinary albumin excretion, starting at concentrations that once were considered healthy (1). We recently reported that, after prolonged frozen storage of urine samples, albumin concentrations may decrease, particularly those within the reference and microalbuminuric intervals(2). We also observed sample variation in the extent to which urinary albumin concentrations (UAC) decreased. In 2005, to investigate whether outcome predictions based on albuminuria were affected by assessment of UAC from frozen samples, we reassessed UAC in Prevention of Renal and Vascular ENdstage Disease (PREVEND) study baseline urine samples, collected and stored frozen at –20 °C from 1997 to 1998. The PREVEND study was approved by the local medical ethics committee and conducted in accordance with the guidelines of the Declaration of Helsinki(3).

The PREVEND dataset was enriched for albuminuria. To create a representative sample . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 J. Am. Soc. Nephrol.Home page
L. Jorgensen, I. Heuch, T. Jenssen, and B. K. Jacobsen
Association of Albuminuria and Cancer Incidence
J. Am. Soc. Nephrol., May 1, 2008; 19(5): 992 - 998.
[Abstract] [Full Text] [PDF]

Home page
 CJASNHome page
R. S. Parekh, W.H. L. Kao, L. A. Meoni, E. Ipp, P. L. Kimmel, J. La Page, C. Fondran, W. C. Knowler, M. J. Klag, and and the Family Investigation of Nephropathy and Di
Reliability of Urinary Albumin, Total Protein, and Creatinine Assays after Prolonged Storage: The Family Investigation of Nephropathy and Diabetes
Clin. J. Am. Soc. Nephrol., November 1, 2007; 2(6): 1156 - 1162.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
J. W. Brinkman, D. de Zeeuw, H. J. Lambers Heerspink, R. T. Gansevoort, I. P. Kema, P. E. de Jong, and S. J.L. Bakker
Apparent Loss of Urinary Albumin during Long-term Frozen Storage: HPLC vs Immunonephelometry
Clin. Chem., August 1, 2007; 53(8): 1520 - 1526.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Association for Clinical Chemistry.