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Clinical Chemistry 53: 1979-1981, 2007; 10.1373/clinchem.2007.092437
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(Clinical Chemistry. 2007;53:1979-1981.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

C-Reactive Protein (CRP) in Neonates: Comparing VITROS Slide and High-Sensitivity CRP Methods

Phillip R. Bach1,a, Brian W. Davis2, David Loughmiller3, Janet Oertli4 and Jacquie Taylor5

1 Primary Children’s Medical Center Department of Pathology Salt Lake City, UT
2 Utah Valley Regional Medical Center, Provo, UT
3 Dixie Regional Medical Center St. George, UT
4 Primary Children’s Medical Center Salt Lake City, UT
5 McKay-Dee Hospital Center Ogden, UT

aAddress correspondence to this author at: Primary Children’s Medical Center, Department of Pathology, 100 N. Medical Dr., Salt Lake City, UT 84113-1100. Fax (801) 662-2165; e-mail phil.bach@intermountainmail.org.

The first 20% of the full text of this article appears below.


To the Editor:

C-reactive protein (CRP) is measured on VITROS® Chemistry Systems (Ortho-Clinical Diagnostics) using a "MicroSlide" method. At our hospitals plasma CRP concentrations <10 mg/L are used as an indicator that it is safe to discontinue antibiotic therapy in neonates with known or suspected sepsis (1). After implementing the neonatal sepsis protocol, we found that the VITROS CRP slide gave results up to 33 mg/L higher in neonatal specimens (Fig. 1 , open triangles) than the Behring Nephelometer II (BNII, Dade Behring) high-sensitivity CRP (hsCRP) assay, a well-characterized method for CRP measurements(2).


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  		Figure 1. Bland-Altman plot showing the difference between CRP by VITROS and comparative methods.

{Delta}, VITROS CRP Slide vs Behring Nephelometer II. {blacksquare}, VITROS hsCRP MicroTip method vs Behring Nephelometer II, DPC IMMULITE, or Roche Integra. Dotted vertical line is the . . . [Full Text of this Article]






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Copyright © 2007 by the American Association for Clinical Chemistry.