Clinical Chemistry
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Clinical Chemistry 53: 1986-1987, 2007; 10.1373/clinchem.2007.091371
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(Clinical Chemistry. 2007;53:1986-1987.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

The Effect of Freezing, Thawing, and Short- and Long-Term Storage on Serum Thyrotropin, Thyroid Hormones, and Thyroid Autoantibodies: Implications for Analyzing Samples Stored in Serum Banks

Tuija Männistö1,2,a, Heljä-Marja Surcel3, Aini Bloigu3, Aimo Ruokonen4, Anna-Liisa Hartikainen1, Marjo-Riitta Järvelin2,5, Anneli Pouta3, Marja Vääräsmäki1 and Eila Suvanto-Luukkonen1

Departments of1 Obstetrics and Gynecology and2 Public Health Science and General Practice University of Oulu Oulu, Finland
3 National Public Health Institute Oulu, Finland
4 Department of Clinical Chemistry University of Oulu Oulu, Finland
5 Department of Epidemiology and Public Health Imperial College London London, United Kingdom

aAddress correspondence to this author at: Department of Obstetrics and Gynecology, University of Oulu, PO Box 5000, 90014 Oulu, Finland. Fax 358-8-3154310; e-mail Tuija.Mannisto@oulu.fi.

The first 20% of the full text of this article appears below.


To the Editor:

Data concerning the effects of freezing, thawing, and storage on serum thyroid-stimulating hormone (TSH) and thyroid hormones [free thyroxine (fT4) and free triiodothyronine (fT3)] are scarce (1)(2)(3), and we can find no data on their effects on thyroid autoantibodies [thyroid-peroxidase antibody (TPO-Ab) and thyroglobulin antibody (TG-Ab)].

We evaluated the effect of freezing, thawing, and storage of samples for up to 23 years on TSH, fT4, fT3, TPO-Ab, and TG-Ab concentrations in human serum (Architect i2000, Abbott Diagnostics). Whole blood samples for the Finnish Maternity Cohort (FMC) were collected without preservative from pregnant women, most of whom were in the 1st trimester of pregnancy. Each sample was stored in a single serum aliquot in a polypropylene cryovial (Nunc GmbH & Co.) at –25 °C. The ethics boards of the Finnish National Public Health Institute and Oulu University Hospital approved . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 J. Clin. Endocrinol. Metab.Home page
T. Mannisto, M. Vaarasmaki, A. Pouta, A.-L. Hartikainen, A. Ruokonen, H.-M. Surcel, A. Bloigu, M.-R. Jarvelin, and E. Suvanto-Luukkonen
Perinatal Outcome of Children Born to Mothers with Thyroid Dysfunction or Antibodies: A Prospective Population-Based Cohort Study
J. Clin. Endocrinol. Metab., March 1, 2009; 94(3): 772 - 779.
[Abstract] [Full Text] [PDF]


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