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Clinical Chemistry 53: 2219-2221, 2007; 10.1373/clinchem.2007.094946
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(Clinical Chemistry. 2007;53:2219-2221.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Effect of Corticosteroid Therapy on Low-Molecular–Weight Protein Markers of Kidney Function

Arend Bökenkamp1,a, Cèleste A.R.C. Laarman1, Katja I. Braam1, Joanna A.E. van Wijk1, Wijnanda A. Kors1, Marijke Kool1, Janneke de Valk1, Anna A. Bouman2, Marieke D. Spreeuwenberg3 and Birgit Stoffel-Wagner4

Departments of1 Pediatrics, 2 Clinical Chemistry, and
3 Clinical Epidemiology and, Biostatistics, VU Medical Center, Amsterdam, The Netherlands
4 Department of Clinical, Biochemistry, Bonn University, Medical Center, Bonn, Germany

aAddress correspondence to this author at: Department of Pediatrics, Vrije Universiteit Medical Center, De Boelelaan 1117, NL-1081 HV Amsterdam. Fax 31-20–4440849; e-mail Bokenkamp@VUmc.nl.

The first 20% of the full text of this article appears below.


To the Editor:

Serum cystatin C, β2-microglobulin, and β-trace protein are endogenous markers of glomerular filtration rate (GFR). Cystatin C, in particular, is a promising alternative to creatinine for the detection of incipient renal failure. However, corticosteroids affect the extrarenal metabolism of cystatin C, which limits the use of cystatin C as a marker of GFR in a variety of clinical settings. Low-molecular–weight (LMW) β-trace protein might be a useful alternative in this respect. The present study set out to compare the effect of corticosteroid therapy on the serum concentrations of cystatin C, β2-microglobulin, and β-trace protein.

We studied a group of 108 children being treated or followed for malignancy (n = 41) or renal disease (n = 67). In the former group 14 patients (34%) were treated with glucocorticoids, in the latter 18 (27%). We compared single-injection inulin clearance studies in 76 patients not receiving steroids with 32 in patients receiving corticosteroid treatment (median dose 33.0 mg prednisone-equivalent per m2 body surface . . . [Full Text of this Article]






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