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The authors of the article cited above respond:

Department of Clinical Biochemistry, Aarhus Sygehus, Aarhus University Hospital, 8000 Aarhus, Denmark.

^aAddress correspondence to this author at: Department of Clinical Biochemistry, Aarhus Sygehus, Aarhus University Hospital, 8000 Aarhus, Denmark.

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To the Editor:

Dr. Carmel was the first to report that total haptocorrin (HC) and cobalamins are related and that this relationship may be associated with the occurrence of heterozygosity for HC deficiency (1). The rarity of HC deficiency, however, suggests that this explanation is probably incomplete. Furthermore, a continuous relationship exists between HC and cobalamins, not the stepwise one that would occur if simple gene dosage were the mechanism. Therefore we—and Carmel, according to his letter—believe that the genetic factors determining HC concentrations are more complex. Obviously, further studies are needed to give a clear picture of the relationship between such factors and the concentration of HC. So far, Carmel has demonstrated a relationship between . . . [Full Text of this Article]