Clinical Chemistry
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Clinical Chemistry 53: 795-796, 2007; 10.1373/clinchem.2006.078840
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(Clinical Chemistry. 2007;53:795-796.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Liposomal Amphotericin B Interferes with the Phosphorus Assay on the Synchron LX 20 Analyzer

Helen L. Bailey1 and Emily M. Chan2

1 Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94110
2 Clinical Laboratory, University of California San Francisco Medical Center, San Francisco, CA 94110

*Address correspondence to this author at: The Department of Laboratory Medicine, University of California San Francisco, 505 Parnasus Ave., M-580, San Francisco, CA 94143-0102; fax 415-206-6996; e-mail Helen.bailey@ucsfmedctr.org.

The first 20% of the full text of this article appears below.


To the Editor:

We report an interference caused by liposomal amphotericin B (AmBisome, Astellas Pharma) in the Synchron LX 20 (Beckman Coulter) phosphorus assay (PHOSm). Two inpatients treated with liposomal amphotericin B for invasive mucormycosis were noted to have significantly increased serum phosphorus concentrations. Serum phosphorus values from patient A ranged from 0.9 mmol/L to 3.1 mmol/L compared with pretreatment values of 0.7 to 0.9 mmol/L (reference interval, 0.8–1.5 mmol/L). Patient B was transferred to our institution after 23 days of amphotericin treatment and had phosphorus values ranging from 1.4 to 3.9 mmol/L. Both patients had slightly increased but stable serum creatinine concentrations (53.0–185.6 µmol/L) and did not exhibit symptoms of hyperphosphatemia. One attending physician suspected a possible interference in the phosphorus assay and contacted the clinical laboratory to initiate investigation.

In contrast to the markedly increased phosphorus values from the Synchron LX20 analyzer, the . . . [Full Text of this Article]






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Copyright © 2007 by the American Association for Clinical Chemistry.