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Clinical Chemistry 53: 995-996, 2007; 10.1373/clinchem.2007.086199
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(Clinical Chemistry. 2007;53:995-996.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Myocardial Infarction with Normal Coronary Arteries: A Role for MRI?

Matthew W. Martinez1, Luciano Babuin1, Imran S. Syed1, Da-Li Feng1, Wayne L. Miller1, Verghese Mathew1, Jerome F. Breen2 and Allan S. Jaffe1,3,a

1 Division of Cardiovascular Diseases, Mayo Graduate School
2 Department of Radiology
3 Department of Laboratory, Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN

aAddress correspondence to this author at: CV Division, Gonda 5, 200 First St., SW, Rochester, MN 55905. Fax 507-266-0228; e-mail Jaffe.Allan@mayo.edu.

The first 20% of the full text of this article appears below.


To the Editor:

We recently cared for several patients with chest discomfort characteristic of coronary disease, electrocardiogram (ECG) changes, and increasing troponin concentrations. Coronary angiography revealed mild or no coronary artery disease (CAD), so we evaluated these patients with contrast-enhanced cardiac MRI. Our data suggest that these patients had myocardial infarction (MI).

With Institutional Review Board permission, we reviewed our angiography database for patients with normal coronary arteries or mild coronary artery disease during the period from January 2005 to November 1, 2006, to augment those cases we found clinically. Inclusion criteria included presentation with acute coronary syndrome, increased serum troponin T concentration (>0.01 µg/L), or mild or absent CAD by angiography and a contrast-enhanced cardiac MRI (CE-CMR) considered diagnostic for infarction. Patients with prior infarction, known CAD, heart failure, pulmonary embolism, or suspected pericarditis/myocarditis were excluded. Eight patients met these criteria. All angiogram results were reviewed by one of the investigators (V.M.).

CE-CMR studies . . . [Full Text of this Article]




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Home page
 Clin. Chem.Home page
A. S. Jaffe
Key Issues in the Developing Synergism between Cardiovascular Imaging and Biomarkers
Clin. Chem., September 1, 2008; 54(9): 1432 - 1442.
[Abstract] [Full Text] [PDF]


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