Clinical Chemistry Link to Randox Laboratories Web Site
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Clinical Chemistry 53: 1159-a-1161-a, 2007; 10.1373/clinchem.2007.089300
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an electronic Letter to
the Editor about this paper
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chang, Y.
Right arrow Articles by Jang, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chang, Y.
Right arrow Articles by Jang, Y.
Related Collections
Right arrow Lipids, Lipoproteins, and Cardiovascular Risk Factors
(Clinical Chemistry. 2007;53:1159-1161.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Reply to Alanine Aminotransferase as an Independent Predictor of Incident Nonalcoholic Fatty Liver Disease

Yoosoo Chang1, Seungho Ryu2,a, Eunju Sung3 and Yumi Jang4

1 Health Screening Center
2 Department of Occupational, Medicine and
3 Department of Family Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea
4 Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, Korea

aAddress correspondence to this author at: Kangbuk Samsung Hospital, 108 Pyung dong, Jongro-Gu, Seoul, Korea 110-746. Fax 82-2-2001-2626; e-mail sh703.yoo@samsung.com.

The first 20% of the full text of this article appears below.


To the Editor:

First, the relationship between alanine aminotransferase (ALT) and nonalcoholic fatty liver disease (NAFLD) has not yet been clearly established, although increased liver enzymes are usually used as a surrogate marker of NAFLD. Tagher et al. have also noted that liver enzymes may be within the reference interval in up to 70% of patients diagnosed with NAFLD and that the full histological spectrum of NAFLD may be present in patients with normal liver enzymes. Our observations were therefore novel and have potential importance in understanding the relationship between ALT and NAFLD. Furthermore, several issues need to be clarified about ALT, including the isoforms of ALT and the role of different ALT isoforms in humans (1).

Second, regarding the adjustment of confounders, such as insulin resistance, we did not perform this study using the euglycemic clamp and cannot comment on Tagher’s concerns about the interrelation between ALT, NAFLD, and insulin resistance as assessed by the euglycemic clamp . . . [Full Text of this Article]






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2007 by the American Association for Clinical Chemistry.