Clinical Chemistry
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Clinical Chemistry 53: 1715-a-1716-a, 2007; 10.1373/clinchem.2007.089763
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(Clinical Chemistry. 2007;53:1715-1716.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

A Recommended Improvement for Specifying and Estimating Serum Creatinine Performance

Jan S. Krouwer

Krouwer Consulting, 26 Parks Drive, Sherborn, MA 01770, Fax 1-508-647-9380, E-mail jan.krouwer@comcast.net

The first 20% of the full text of this article appears below.


To the Editor:

Myers et al. (1) discuss the importance of creatinine analytical performance in the estimation of the glomerular filtration rate. They correctly specify a model of assay performance but subsequently do not seem to use that model. I suggest a variation of their model that is less subject to misinterpretation. The Myers et al. (1) model is:

Formula 1(1)
where Y is a result of a field creatinine assay, bias is the average bias between Y and a reference method for creatinine measurement, and imprecision includes imprecision sources from short-term (within-run or repeatability) and long-term (within-laboratory or reproducibility) and random patient interferences [called specimen-specific effects by Myers et al. (1)]. Here we refer to the 1st 2 sources . . . [Full Text of this Article]




The following articles in journals at HighWire Press have cited this article:


Home page
 Clin. Chem.Home page
C. M. Cobbaert, H. Baadenhuijsen, and C. W. Weykamp
Prime Time for Enzymatic Creatinine Methods in Pediatrics
Clin. Chem., March 1, 2009; 55(3): 549 - 558.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
W. G. Miller, G. L. Myers, and J. H. Eckfeldt
The authors of the article cited above respond:
Clin. Chem., September 1, 2007; 53(9): 1716 - 1717.
[Full Text] [PDF]


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