Clinical Chemistry
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Clinical Chemistry 53: 1717-1718, 2007; 10.1373/clinchem.2007.091421
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(Clinical Chemistry. 2007;53:1717-1718.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Measurements of Free Hemoglobin and Hemolysis Index: EDTA- or Lithium-Heparinate Plasma?

Janne Ungera, Gerlinde Filippi and Wolfgang Patsch

Paracelsus Medical University, and Landeskliniken Salzburg, Department of Clinical Chemistry, Salzburg, Austria

aAddress correspondence to this author at: Department of Clinical Chemistry, Paracelsus Medical University and Landeskliniken Salzburg, Müllner Hauptstraße 48, 5020 Salzburg, Austria. Fax 43-662-4482-885; e-mail: j.unger@salk.at.

The first 20% of the full text of this article appears below.

There is no agreement as to the optimal sample type to be used for measurements of free hemoglobin (fHb) in plasma. (Because fHb is increased during clotting, serum is not recommended.) Several publications have recommended the use of EDTA as an anticoagulant (2), but another author reported 20-fold higher fHb values in EDTA-plasma than in Li-heparinate plasma and therefore recommended Li-heparinate plasma for such analyses (1). Because Li-heparinate and EDTA plasma are often used for emergency and routine measurements, we explored this issue and searched for a practicable, inexpensive, and rapid method for fHb measurements.

Blood from 49 patients was collected into sample tubes (Monovette, Sarstedt) containing EDTA (1.6 g/L of whole blood) or Li-heparinate (16 kIE/L of whole blood). Samples were collected from patients who required laboratory analyses. Patients gave informed consent, and . . . [Full Text of this Article]






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