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Clinical Chemistry 53: 1721-1722, 2007; 10.1373/clinchem.2007.092338
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(Clinical Chemistry. 2007;53:1721-1722.)
© 2007 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Genetic Factors for Warfarin Dose Prediction

Giuseppe Lippia, Gian Luca Salvagno and Gian Cesare Guidi

Sezione di Chimica Clinica, Dipartimento di Scienze, Morfologico-Biomediche, Università degli Studi di Verona, Verona, Italy

aAddress correspondence to this author at: Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università degli Studi di Verona, Ospedale Policlinico G.B. Rossi, Piazzale Scuro, 10, 37134 Verona, Italy. Fax 0039-045-8201889; e-mail ulippi@tin.it.

The first 20% of the full text of this article appears below.


To the Editor:

Warfarin, a commonly prescribed anticoagulant drug used to prevent thrombosis, has a narrow therapeutic range, and small dose variations may result in hemorrhagic or thrombotic complications. The 2 key enzymes in the metabolism of warfarin are cytochrome P450 (CYP) 2C9 (CYP2C9 gene) and the C1 subunit of the vitamin K 2,3 epoxide reductase complex (VKORC1 gene). CYP2C9 accounts for up to 85% of the metabolism of the pharmacologically more potent S-warfarin enantiomer, and VKORC1, the 2nd key enzyme in warfarin metabolism, is responsible for recycling reduced vitamin K. In their recent article, Zhu et al. (1) concluded that . . . [Full Text of this Article]






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Copyright © 2007 by the American Association for Clinical Chemistry.