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Clinical Chemistry 54: 2086-2087, 2008; 10.1373/clinchem.2008.113795
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(Clinical Chemistry. 2008;54:2086-2087.)
© 2008 American Association for Clinical Chemistry, Inc.

Letters to the Editor

Concerns Regarding Lipoprotein Particle Measurement by Ion Mobility Analysis

James D. Otvos2,a, Lawrence L. Rudel3 and Joseph P. McConnell4

2 LipoScience, Inc. Raleigh, NC
3 Department of Pathology Section on Lipid Sciences Wake Forest University School of Medicine Winston-Salem, NC
4 Department of Laboratory Medicine and Pathology Mayo Clinic Rochester, MN

aAddress correspondence to this author at: LipoScience, Inc. 2500 Sumner Blvd. Raleigh, NC 27616. E-mail jotvos@liposcience.com.

The first 20% of the full text of this article appears below.


To the Editor:

We read with interest the report by Caulfield et al. (1) describing a new method for measuring lipoprotein particle concentrations by ion mobility (IM)1 analysis. There is growing evidence that the LDL particle concentration, as assessed by apolipoprotein B (apo B) or nuclear magnetic resonance (NMR) measurements, is a better discriminator of cardiovascular risk than the LDL cholesterol concentration, and measures of VLDL and HDL particles have also been suggested to have clinical advantages over analyses of their lipid counterparts. For these reasons, methods capable of quantifying lipoprotein particle concentrations accurately and efficiently are of considerable interest, and we congratulate the authors on their efforts.

As part of the validation of the IM method, Caulfield and colleagues present several plots that compare IM-measured particle concentrations with corresponding lipid or apolipoprotein measurements. The results of some of these comparisons do not agree with expectations and raise concerns in our minds about the accuracy of the measured particle concentrations. As the authors point . . . [Full Text of this Article]




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 Arterioscler. Thromb. Vasc. Bio.Home page
K. Musunuru, M. Orho-Melander, M. P. Caulfield, S. Li, W. A. Salameh, R. E. Reitz, G. Berglund, B. Hedblad, G. Engstrom, P. T. Williams, et al.
Ion Mobility Analysis of Lipoprotein Subfractions Identifies Three Independent Axes of Cardiovascular Risk
Arterioscler Thromb Vasc Biol, November 1, 2009; 29(11): 1975 - 1980.
[Abstract] [Full Text] [PDF]


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